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First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor

dc.contributor.authorFjellaksel, Richard
dc.contributor.authorOteiza, Ana
dc.contributor.authorMartin, armas maria montserrat
dc.contributor.authorRiss, Patrick
dc.contributor.authorHjelstuen, Ole Kristian
dc.contributor.authorKuttner, Samuel
dc.contributor.authorHansen, Jørn H
dc.contributor.authorSundset, Rune
dc.date.accessioned2019-02-08T11:46:39Z
dc.date.available2019-02-08T11:46:39Z
dc.date.issued2018-11-09
dc.description.abstract<p><i>Objectives</i>: In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.</p> <p><i>Results</i>: We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature findings showed similar alpha-halogenated compounds suitable for in vivo evaluations. The compound was found to possess nano molar affinity for the gonadotropin releasing hormone-receptor in a competition dependent inhibition study. Furthermore, liquid chromatography-mass spectrometry analysis in saline, human and rat serum resulted in 46%, 52% and 44% stability after incubation for 1 h respectively. In addition, rat brain single photon emission computed tomography and biodistribution studies gave further insight into the nature of the compound as a radiotracer.</p>en_US
dc.description.sponsorshipHelse Nord The department of Chemistry at UiT The Arctic University of Norway UiT The Arctic University of Norwayen_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s13104-018-3924-2> https://doi.org/10.1186/s13104-018-3924-2</a>. Licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationFjellaksel, R., Oteiza, A., Martin-Armas, M., Riss, P.J., Hjelstuen, O.K., Kuttner, S., ... Sundset, R. (2018). First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor. <i>BMC Research Notes, 11</i>(811). https://doi.org/10.1186/s13104-018-3924-2en_US
dc.identifier.cristinIDFRIDAID 1631093
dc.identifier.doi10.1186/s13104-018-3924-2
dc.identifier.issn1756-0500
dc.identifier.urihttps://hdl.handle.net/10037/14656
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Research Notes
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectAlpha-halogenationen_US
dc.subjectSPECTen_US
dc.subjectGnRHen_US
dc.subjectRadiotraceren_US
dc.subjectGonadotropinen_US
dc.titleFirst in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptoren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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