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dc.contributor.authorWagner, Theresa
dc.contributor.authorJames Peter, Jessin Janice
dc.contributor.authorPaganelli, Fernanda
dc.contributor.authorWillems, Rob J.L.
dc.contributor.authorAskarian, Fatemeh
dc.contributor.authorPedersen, Torunn Annie
dc.contributor.authorTop, Janetta
dc.contributor.authorde Haas, Carla
dc.contributor.authorvan strijp, Jos A. G.
dc.contributor.authorJohannessen, Mona
dc.contributor.authorHegstad, Kristin
dc.date.accessioned2019-02-25T11:24:54Z
dc.date.available2019-02-25T11:24:54Z
dc.date.issued2018-12-03
dc.description.abstract<i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> mainly play a role in adherence and biofilm production, while less is known about factors contributing to survival in blood. This study identified a gene cluster, which includes genes encoding bacterial Toll/interleukin-1 receptor- (TIR-) domain-containing proteins (TirEs). The cluster was found to be unique to nosocomial strains and to be located on a putative mobile genetic element of phage origin. The three genes within the cluster appeared to be expressed as an operon. Expression was detected in bacterial culture media and in the presence of human blood. TirEs are released into the bacterial supernatant, and TirE2 is associated with membrane vesicles. Furthermore, the <i>tirE</i>-gene cluster promotes bacterial proliferation in human blood, indicating that TirE may contribute to the pathogenesis of bacteremia.en_US
dc.description.sponsorshipThe Northern Norway Regional Health Authority Medical Research Program UiT The Arctic University of Norwayen_US
dc.descriptionSource at <a href=https://doi.org/10.1155/2018/1435820> https://doi.org/10.1155/2018/1435820</a>.en_US
dc.identifier.citationWagner, T.M., Janice, J., Paganelli, F.L., Willems, R.J., Askarian, F., Pedersen, T.P., ... Hegstad, K. (2018). Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood. <i>International Journal of Microbiology</i>. https://doi.org/10.1155/2018/1435820en_US
dc.identifier.cristinIDFRIDAID 1648911
dc.identifier.doi10.1155/2018/1435820
dc.identifier.issn1687-918X
dc.identifier.issn1687-9198
dc.identifier.urihttps://hdl.handle.net/10037/14760
dc.language.isoengen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.journalInternational Journal of Microbiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FORSKSKOLE/249062/Norway/Norwegian Research School in Infection Biology and Antimicrobials/IBA/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en_US
dc.titleEnterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blooden_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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