Show simple item record

dc.contributor.authorWinther, Anne
dc.contributor.authorJørgensen, Lone
dc.contributor.authorAhmed, Luai A.
dc.contributor.authorChristoffersen, Tore
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorGrimnes, Guri
dc.contributor.authorJorde, Rolf
dc.contributor.authorNilsen, Ole-Andreas
dc.contributor.authorDennison, Elaine M.
dc.contributor.authorEmaus, Nina
dc.date.accessioned2019-03-06T09:15:15Z
dc.date.available2019-03-06T09:15:15Z
dc.date.issued2018-01-19
dc.description.abstract<p><i>Background</i>: Positive association between body weight and bone mass is well established, and the concept of body mass index (BMI) is associated with higher areal bone mineral density (aBMD) and reduced fracture risk. BMI, that comprises both fat mass (FM) and lean mass (LM) may contribute to peak bone mass achievement in different ways. This study explored the influence of body composition in terms of total body LM and FM on hip aBMD-values in adolescence.</p> <p><i>Methods</i>: In 2010/2011, 93% of the region’s first-year upper-secondary school students (15–17 years old) in Tromsø, Norway attended the Tromsø Study, Fit Futures. Areal BMD at femoral neck (aBMDFN) and total hip (aBMDTH) (g/cm2), total body LM and FM (g) were measured by dual energy X-ray absorptiometry (DXA). Height and weight were measured, and BMI calculated. Lifestyle variables were collected by self-administered questionnaires and interviews, including questions on time spent on leisure time physical activity. Stratified analyses of covariance and regression models included 395 girls and 363 boys. Crude results were adjusted for age, height, sexual maturation, physical activity levels, vitamin D levels, calcium intake, alcohol consumption and smoking habits.</p> <p><i>Results</i>: Unadjusted distribution indicated higher aBMD-levels at higher LM-levels in both genders (p < 0.001), but higher aBMD at higher FM-levels were found only in girls (p < 0.018). After multiple adjustments, aBMDFN-levels in girls were associated by 0.053 g/cm2 and 0.032 g/cm2 per standard deviation (SD) change in LM and FM (p < 0.001). Corresponding values in boys were 0.072 and 0.025 (p < 0.001). The high LM groups accounted for the highest aBMD-levels, while aBMD-levels at the LM/FM-combinations indicated different patterns in girls compared to boys. The adjusted odds ratio (95% CI) for low levels of aBMDFN was 6.6 (3.4,13.0) in boys, compared to 2.8 (1.6,4.9) in girls per SD lower LM.</p> <p><i>Conclusions</i>: LM and FM should be regarded as strong predictors for bone mass and hence bone strength in adolescents. A gender specific difference indicated that high lean mass is of crucial importance prominently in boys. In adolescents with low lean mass, especially in girls, high fat mass may partially ameliorate the effect of deficient lean mass levels.</p>en_US
dc.description.sponsorshipNorthern Norway Regional Health Authority (Helse Nord RHF) The Norwegian Osteoporosis Associationen_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12891-018-1933-x> https://doi.org/10.1186/s12891-018-1933-x</a>. Licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationWinther, A., Jørgensen, L., Ahmed, L.A., Christoffersen, T., Furberg, A.-S., Grimnes, G., ... Emaus, N. (2018). Bone mineral density at the hip and its relation to fat mass and lean mass in adolescents: the Tromsø Study, Fit Futures. <i>BMC Musculoskeletal Disorders, 19</i>(21). https://doi.org/10.1186/s12891-018-1933-xen_US
dc.identifier.cristinIDFRIDAID 1574586
dc.identifier.doi10.1186/s12891-018-1933-x
dc.identifier.issn1471-2474
dc.identifier.urihttps://hdl.handle.net/10037/14857
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Musculoskeletal Disorders
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectaBMDen_US
dc.subjectFat massen_US
dc.subjectLean massen_US
dc.subjectDXAen_US
dc.subjectAdolescentsen_US
dc.subjectPopulation-based studyen_US
dc.titleBone mineral density at the hip and its relation to fat mass and lean mass in adolescents: the Tromsø Study, Fit Futuresen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record