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dc.contributor.authorMelsom, Toralf
dc.contributor.authorSolbu, Marit Dahl
dc.contributor.authorSchei, Jørgen
dc.contributor.authorStefansson, Vidar Tor Nyborg
dc.contributor.authorNorvik, Jon Viljar
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorEriksen, Bjørn Odvar
dc.date.accessioned2019-03-08T12:23:39Z
dc.date.available2019-03-08T12:23:39Z
dc.date.issued2018-02-08
dc.description.abstract<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, cardiovascular, or chronic kidney disease.<p> <p><i>Methods</i>: In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1567 middle-aged nondiabetic individuals with an ACR <3.40 mg/mmol (30.0 mg/g) at baseline. The ACR was measured in unfrozen morning urine samples collected on 3 days before the GFR measurements. A total of 1278 (81%) participants had follow-up with GFR measurements after a median of 5.6 years.<p> <p><i>Results</i>: The median ACR at baseline was 0.22 mg/mmol (interquartile range: 0.10-0.51 mg/mmol), the mean ± SD GFR was 104.0 ± 20.1 ml/min, and the mean ± SD GFR decline rate was -0.95 ± 2.23 ml/min per year. Higher baseline ACR levels were associated with a steeper GFR decline in adjusted linear mixed models. Study participants with ACR levels of 0.11 to 0.45 and 0.46 ± 3.40 mg/mmol had a 0.25 ml/min per year (95% confidence interval [95% CI]: -0.03 to 0.53) and 0.31 ml/min per year (95% CI: 0.02-0.60) steeper rate of decline than those with ACR ≤0.10 mg/mmol in multivariable-adjusted analyses. Among study participants with an ACR of <1.13 mg/mmol (defined as the optimal range), those with an ACR of 0.11 to 1.12 mg/mmol (n = 812) had a 0.28 ml/min per year (95% CI: 0.04-0.52) steeper rate of GFR decline than those with an ACR of ≤0.10 mg/mmol (n = 655).<p> <p><i>Conclusion</i>: A mildly increased ACR is an independent risk factor for faster GFR decline in nondiabetic individuals.<p>en_US
dc.description.sponsorshipNorthern Norway Regional Health Authority Boehringer-Ingelheimen_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.ekir.2018.01.015>https://doi.org/10.1016/j.ekir.2018.01.015. </a>en_US
dc.identifier.citationMelsom, T., Solbu, M.D., Schei, J., Stefansson, V.T.N., Norvik, J.V., Jenssen, T.G. ... Eriksen, B.O. (2018). Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population. <i>Kidney International Reports, 3</i>(4), 817-824. https://doi.org/10.1016/j.ekir.2018.01.015en_US
dc.identifier.cristinIDFRIDAID 1592407
dc.identifier.doi10.1016/j.ekir.2018.01.015
dc.identifier.issn2468-0249
dc.identifier.urihttps://hdl.handle.net/10037/14912
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalKidney International Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectACRen_US
dc.subjectalbumin-creatinine-ratioen_US
dc.subjectGFRen_US
dc.subjectiohexol clearanceen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleMild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Populationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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