Show simple item record

dc.contributor.advisorBorch, Kristin Benjaminsen
dc.contributor.authorEndal, Håkon Kaurin
dc.date.accessioned2019-03-11T10:57:47Z
dc.date.available2019-03-11T10:57:47Z
dc.date.issued2018-12-11
dc.description.abstractObjective: The purpose of this thesis is to identify and investigate risk factors associated with childhood leukemia, formulated by the research question: Which risk factors are associated with parental exposure and childhood leukemia in the offspring? Methods: A systematic literature search was performed in three databases Embase, Medline and Cochrane. The articles found were selected and included when related to the research question. All articles were evaluated for risk of bias and level of evidence using the quality assessment system Grading of Recommendation, Assessment, Development and Evaluation (GRADE). The exposures were divided into several categories, all relevant to parental exposure: air pollution, use of alcohol and medications, occupational exposure, pesticides, socio-economic status (SES) and smoking. Results/Discussion: 27 articles were found and included in the systematic review. Exposure to petroleum and hydrocarbons as well as pesticides appears to increase the risk of childhood leukemia. A high risk of bias was found in several of the studies and GRADE level varied from very low to medium with no studies in the high category. Heterogeneity was high between the studies, both in way of exposure measurement and in exposure category. The lack of differentiation in the outcome between different subtypes of leukemia in childhood was problematic and new research must consider this. Conclusion: There is not enough evidence to support that smoking, use of alcohol or medications and SES are risk factors for childhood leukemia. What we can determine is that pesticides, solvents and petroleum-derivates can be considered as potential risk factors and that timing of exposure is crucial for the development of childhood cancer. However, we cannot conclude that there is any causality between the risk factors and childhood leukemia, nor any of its subtypes. Register-based cohorts with global cooperation, with focus on subgroups, should be performed to better understand the impact of parental exposure and risk of childhood leukemia.en_US
dc.identifier.urihttps://hdl.handle.net/10037/14930
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.holderCopyright 2018 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDHEL-3950
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectEpidemiologyen_US
dc.subjectChildhooden_US
dc.subjectLeukemiaen_US
dc.subjectRisk factorsen_US
dc.subjectParentalen_US
dc.subjectExposureen_US
dc.subjectSystematic reviewen_US
dc.subjectOffspringen_US
dc.titleParental exposure and risk factors for leukemia in offspring. A systematic reviewen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)