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dc.contributor.authorSovershaeva, Evgeniya
dc.contributor.authorShamu, Tinei
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorBandason, Tsitsi
dc.contributor.authorFlægstad, Trond
dc.contributor.authorKatzenstein, David
dc.contributor.authorFerrand, Rashida A.
dc.contributor.authorOdland, Jon Øyvind
dc.date.accessioned2019-03-20T12:03:05Z
dc.date.available2019-03-20T12:03:05Z
dc.date.issued2018-10-31
dc.description.abstract<i>Objective</i>: To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe.<p> <p><i>Methods</i>: Children (0–19 years) and adults (>19 years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years, respectively. The incidence rates of virological failure (VF), low-level viraemia (LLV), and viral blips were assessed and the predictors of viraemia were determined using logistic and parametric survival regression analyses.<p> <p><i>Results</i>: A total of 630 individuals initiated ART, and 19.7% of children and 5.6% of adults did not achieve viral suppression by 12 months. Younger age and CD4 count 200 cells/mm<sup>3</sup> at baseline were associated with not being virally suppressed at 12 months in adults. Among those who achieved viral suppression during the follow-up period, the incidence of VF was higher in children (4.0/100 person-years vs. 0.4/100 person-years in adults; <i>p</i><0.001), as was the incidence of LLV (1.9/100 person-years vs. 0.3/100 person-years in adults; <i>p</i> = 0.03). The incidence rate of blips was 10.9 per 100 person-years in children and 4.0 per 100 person-years in adults.<p> <p><i>Conclusions</i>: Children are less likely to reach viral suppression and are at higher risk of viraemia while on ART than adults. The significance of LLV and blips needs further study.<p>en_US
dc.description.sponsorshipHelseNord Wellcome Trust Senior Fellowship in Clinical Scienceen_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.ijid.2018.10.019>https://doi.org/10.1016/j.ijid.2018.10.019. </a>en_US
dc.identifier.citationSovershaeva, E., Shamu, T., Wilsgaard, T., Bandason, T., Flægstad, T., Katzenstein, D. ... Odland, J. (2018). Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe. <i>International Journal of Infectious Diseases, 78</i>, 65-71. https://doi.org/10.1016/j.ijid.2018.10.019en_US
dc.identifier.cristinIDFRIDAID 1653145
dc.identifier.doi10.1016/j.ijid.2018.10.019
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.urihttps://hdl.handle.net/10037/15034
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofSovershaeva, E. (2019). HIV-infection in children and adolescents in Zimbabwe: viral suppression, airway abnormalities and gut microbiota. (Doctoral thesis). <a href=https://hdl.handle.net/10037/16909>https://hdl.handle.net/10037/16909</a>.
dc.relation.journalInternational Journal of Infectious Diseases
dc.rights.accessRightsopenAccessen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectHIVen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectViral blipen_US
dc.subjectViral loaden_US
dc.subjectViraemiaen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titlePatterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabween_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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