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dc.contributor.authorKirsebom, Bjørn-Eivind
dc.contributor.authorNordengen, Kaja
dc.contributor.authorSelnes, Per
dc.contributor.authorWaterloo, Knut
dc.contributor.authorTorsetnes, Silje Bøen
dc.contributor.authorGísladóttir, Berglind
dc.contributor.authorBrix, Britta
dc.contributor.authorVanmechelen, Eugeen
dc.contributor.authorBråthen, Geir
dc.contributor.authorHessen, Erik
dc.contributor.authorAarsland, Dag
dc.contributor.authorFladby, Tormod
dc.date.accessioned2019-04-26T09:23:55Z
dc.date.available2019-04-26T09:23:55Z
dc.date.issued2018-11-10
dc.description.abstract<i>Introduction</i>: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in Alzheimer’s disease.<p> <p><i>Methods</i>: We compared Ng/BACE1 levels between cases with subjective cognitive decline (n = 18) and mild cognitive impairment (n 5 20) both with amyloid plaques and healthy controls (<i>APOE-ε</i>4+, n 5 16; <i>APOE-ε</i>4-, n 5 20). We performed regression analyses between cerebrospinal fluid levels, baseline hippocampal and amygdala volumes, and pertinent cognitive measures (memory, attention, Mini Mental State Examination [MMSE]) at baseline and after 2 years.<p> <p><i>Results</i>: Ng/BACE1 levels were elevated in both subjective cognitive decline and mild cognitive impairment compared to healthy controls. Higher Ng/BACE1 ratio was associated with lower hippocampal and amygdala volumes; lower baseline memory functions, attention, and MMSE; and significant decline in MMSE and memory function at 2-year follow-up.<p> <p><i>Discussion</i>: High Ng/BACE1 ratio predicts cognitive decline also in preclinical cases with amyloid plaques.<p>en_US
dc.description.sponsorshipNorwegian Research Council NASATS (Dementia Disease Initiation) JPND Helse Sør-Øst Helse Nord National Institute for Health Research (NIHR) Biomedical Research Center at South London Maudsley NHS Foundation Trust King’s College Londonen_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.trci.2018.10.003>https://doi.org/10.1016/j.trci.2018.10.003. </a>en_US
dc.identifier.citationKirsebom, B-E., Nordengen, K., Selnes, P., Waterloo, K., Torsetnes, S.B, Gísladóttir, B. ... Fladby, T. (2018). Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease. <i>Alzheimer's and Dementia: Translational Research and Clinical Interventions</i>, 4, 617-627. https://doi.org/10.1016/j.trci.2018.10.003en_US
dc.identifier.cristinIDFRIDAID 1642467
dc.identifier.doi10.1016/j.trci.2018.10.003
dc.identifier.issn2352-8737
dc.identifier.urihttps://hdl.handle.net/10037/15232
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofKirsebom, B-E. (2019). Dementia Disease Initiation: Identifying subjective cognitive decline (SCD) due to Alzheimer’s disease. (Doctoral thesis). <a href=https://hdl.handle.net/10037/15234>https://hdl.handle.net/10037/15234. </a>
dc.relation.journalAlzheimer's and Dementia: Translational Research and Clinical Interventions
dc.relation.projectIDinfo:eu-repo/grantAgreement/NRC/?/?/Norway/?//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectMCI (mild cognitive impairment)en_US
dc.subjectSCD (subjective cognitive decline)en_US
dc.subjectMRIen_US
dc.subjectMemoryen_US
dc.subjectCognitionen_US
dc.subjectSynaptic lossen_US
dc.subjectCerebrospinal fluid (CSF)en_US
dc.subjectCSF neurograninen_US
dc.subjectCSF BACE1en_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titleCerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's diseaseen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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