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dc.contributor.advisorVasskog, Terje
dc.contributor.advisorHansen, Espen
dc.contributor.authorAli, Nadia Ghazi
dc.date.accessioned2019-06-25T08:12:50Z
dc.date.available2019-06-25T08:12:50Z
dc.date.issued2019-05-15
dc.description.abstractBacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, which has been a trigger for the work carried out in this thesis. In this thesis, three Arctic marine bacteria of the genus Thalassospira, Alteromonas and Pseudomonas were investigated. The bacterial strains were cultivated, extracted and pre-fractionated. The fractions were screened for antibacterial and anticancer activity, and active fractions were re-fractionated. The bioactive re-fractionated extracts were dereplicated to investigate if the compounds suspected of being active, were novel or had been previously reported. Compounds assumed to be bioactive, as well as those with interesting chemical properties were isolated and characterised. One bioactive compound was isolated from the bacterial strain Thalassospira sp. The compound was active in both antibacterial and anticancer assays, and its structure remains to be elucidated. A di-halogenated compound was also isolated from this strain, it was however found to be chemically unstable. Moreover, three compounds were isolated from the bacterial strain Alteromonas sp. that remain to be structure elucidated and screened for bioactivity.en_US
dc.identifier.urihttps://hdl.handle.net/10037/15601
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)
dc.subject.courseIDFAR-3911
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectFarmasien_US
dc.titleIsolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp.en_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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