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dc.contributor.authorMorelli, Vania Maris
dc.contributor.authorSejrup, Joakim Knutsen
dc.contributor.authorSmåbrekke, Birgit
dc.contributor.authorRinde, Ludvig B
dc.contributor.authorGrimnes, Gro
dc.contributor.authorIsaksen, Trond
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorHindberg, Kristian
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.date.accessioned2019-08-06T12:27:09Z
dc.date.available2019-08-06T12:27:09Z
dc.date.issued2019-02-22
dc.description.abstractStroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. We conducted a populationbased case-crossover study with 707 VTE patients. Triggers were registered during the 90 days before a VTE event (hazard period) and in four preceding 90-day control periods. Conditional logistic regression was used to estimate odds ratios with 95% confidence intervals (CIs) for VTE according to triggers. Stroke was registered in 30 of the 707 (4.2%) hazard periods and in 6 of the 2,828 (0.2%) control periods, resulting in a high risk of VTE, with odds ratios of 20.0 (95% CI: 8.3–48.1). After adjustments for immobilization and infection, odds ratios for VTE conferred by stroke were attenuated to 6.0 (95% CI: 1.6–22.1), and further to 4.0 (95% CI: 1.1–14.2) when other triggers (major surgery, red blood cell transfusion, trauma, and central venous catheter) were added to the regression model. A mediation analysis revealed that 67.8% of the total effect of stroke on VTE risk could be mediated through immobilization and infection. Analyses restricted to ischemic stroke yielded similar results. In conclusion, acute stroke was a trigger for VTE, and the association between stroke and VTE risk appeared to be largely mediated by immobilization and infection.en_US
dc.description.sponsorshipStiftelsen K. G. Jebsen UiT - The Arctic University of Norwayen_US
dc.descriptionSource at <a href=https://doi.org/10.1055/s-0039-1681020>https://doi.org/10.1055/s-0039-1681020</a>.en_US
dc.identifier.citationMorelli, V.M., Sejrup, J.K., Småbrekke, B., Rinde, L., Grimnes, G., Isaksen, T. ... Brækkan, S.K. (2019). The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study. <i>TH Open, 03</i>(01), e50-e57. https://doi.org/10.1055/s-0039-1681020en_US
dc.identifier.cristinIDFRIDAID 1681266
dc.identifier.doi10.1055/s-0039-1681020
dc.identifier.issn2512-9465
dc.identifier.urihttps://hdl.handle.net/10037/15860
dc.language.isoengen_US
dc.publisherThieme Openen_US
dc.relation.journalTH Open
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.subjectvenous thromboembolismen_US
dc.subjectstrokeen_US
dc.subjectrisk factoren_US
dc.subjectimmobilizationen_US
dc.subjectinfectionen_US
dc.titleThe Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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