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dc.contributor.authorHjemsæter, Arne Jan
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorDrake, Robert
dc.contributor.authorMonsbakken, Bent Berntsen
dc.contributor.authorSaltyte Benth, Jurate
dc.contributor.authorLandheim, Anne
dc.date.accessioned2019-10-07T13:29:30Z
dc.date.available2019-10-07T13:29:30Z
dc.date.issued2019
dc.description.abstract<p><i>Background - </i>This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders. <p><i>Methods - </i>This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use disorders. At baseline 291 patients (mean age 38.3 years, standard deviation 11.4 years, 72% male) with high psychiatric co-morbidity were recruited; 130 (45%) had lifetime alcohol use disorder alone, while 161 (55%) had poly-substance use disorders. Time and causes of death were gathered from the Norwegian Cause of Death Registry. Lifetime psychiatric symptom disorders and substance use disorders at baseline were measured with The Composite International Diagnostic Interview and personality disorders at baseline were measured with The Millon Clinical Multiaxial Inventory II. <p><i>Results - </i>Patients with alcohol use disorder alone more often died from somatic diseases (58% versus 28%, p = 0.004) and more seldom from overdoses (9% versus 33%, p = 0.002) compared with patients with poly-substance use disorders. The crude mortality rate per 100 person year was 2.2 (95% confidence interval: 1.8–2.7), and the standardized mortality rate was 3.8 (95% confidence interval: 3.2–4.6) in the entire cohort during 19 years after entering treatment. Having lifetime affective disorder at baseline was associated with lower risk of death (Hazard Ratio 0.58, 95% confidence interval: 0.37–0.91). Older age was associated to increased risk of death among men (p < 0.001) and non-significantly among patients with poly-substance use (p = 0.057). The difference in association between age and risk of death was significantly different between men and women (p = 0.011) and patients with alcohol use disorder alone and poly-substance use disorders (p = 0.041). <p><i>Conclusions - </i>Patients with alcohol use disorder alone died more often from somatic disease than patients with poly-substance use disorders, and all subgroups of patients had an increased risk of death compared with the general population. Men with long-lasting substance use disorders are a priority group to approach with directed preventive measures for somatic health before they reach 50 years of age.en_US
dc.description.sponsorshipInnlandet Hospital Trust Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders University of Oslo.en_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12888-019-2077-8>https://doi.org/10.1186/s12888-019-2077-8</a>.en_US
dc.identifier.citationHjemsæter, A.J., Bramness, J.G., Drake, R., Skeie, I., Monsbakken, B., Saltyte Benth, J. & Landheim, A. (2019). Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study. <i>BMC Psychiatry, 19</i>, 101. https://doi.org/10.1186/s12888-019-2077-8en_US
dc.identifier.cristinIDFRIDAID 1706090
dc.identifier.doi10.1186/s12888-019-2077-8
dc.identifier.issn1471-244X
dc.identifier.urihttps://hdl.handle.net/10037/16342
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Psychiatry
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectMortalityen_US
dc.subjectRisk factorsen_US
dc.subjectSubstance use disordersen_US
dc.subjectAlcoholen_US
dc.subjectPoly-substance use: psychiatric co-morbidityen_US
dc.subjectCause of deathen_US
dc.subjectLongitudinalen_US
dc.titleMortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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