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Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study

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https://hdl.handle.net/10037/16505
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Date
2019-10-14
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei
Abstract
Background - We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also investigated the potential for reverse causation between asthma and risk of adiposity.

Methods - We performed a bidirectional one-sample Mendelian randomisation (MR) study using the Norwegian Nord-Trøndelag Health Study population including 56 105 adults. 73 and 47 genetic variants were included as instrumental variables for body mass index (BMI) and waist-to-hip ratio (WHR), respectively. Asthma was defined as ever asthma, doctor-diagnosed asthma and doctor-diagnosed active asthma, and was further classified by atopic status or levels of symptom control. Causal OR was calculated with the Wald method.

Results - The ORs per 1 SD (4.1 kg/m2) increase in genetically determined BMI were ranged from 1.36 to 1.49 for the three asthma definitions and similar for women and men. The corresponding ORs for non-atopic asthma (range 1.42–1.72) appeared stronger than those for the atopic asthma (range 1.18–1.26), but they were similar for controlled versus partly controlled doctor-diagnosed active asthma (1.43 vs 1.44). There was no clear association between genetically predicted WHR and asthma risk or between genetically predicted asthma and the adiposity markers.

Conclusions - Our MR study provided evidence of a causal association of BMI with asthma in adults, particularly with non-atopic asthma. There was no clear evidence of a causal link between WHR and asthma or of reverse causation.

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This article has been accepted for publication in Thorax, 2019 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/thoraxjnl-2019-213678.

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Publisher
BMJ Publishing Group
Citation
Sun, Y-Q., Brumpton, B.M., Langhammer, A., Chen, Y., Kvaløy, K. & Mai, X-M. (2019). Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study. Thorax, 0:1-7. http://dx.doi.org/10.1136/thoraxjnl-2019-213678
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