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dc.contributor.authorGál, Bernadett Ildikó
dc.contributor.authorKilencz, Tunde
dc.contributor.authorAlbert, Anita
dc.contributor.authorDemeter, Ildikó
dc.contributor.authorHegedűs, Klára Mária
dc.contributor.authorJanka, Zoltán
dc.contributor.authorCsifcsak, Gabor
dc.contributor.authorÁlmos, Péter Zoltán
dc.date.accessioned2019-11-08T13:32:50Z
dc.date.available2019-11-08T13:32:50Z
dc.date.issued2019-09-26
dc.description.abstractNalmefene is approved for as-needed pharmacological treatment in alcohol use disorder (AUD) by the European Medicines Agency. While the cellular effects of nalmefene have been thoroughly investigated, data are very limited on how this agent influences neural signals associated with inhibitory control and the visual analysis of environmental cues. This double-blind crossover study assessed the behavioral and neural effects of acute nalmefene administration in patients diagnosed with AUD. In experiment 1, we validated our experimental paradigm (electroencephalography combined with a modified Go/NoGo task using images of alcoholic and nonalcoholic drinks as prime stimuli) in 20 healthy adults to ensure that our protocol is suitable for assessing the behavioral and neural aspects of executive control. In experiment 2, we recruited 19 patients with AUD, and in a double-blind crossover design, we investigated the effects of nalmefene versus placebo on task performance (response accuracy, the sensitivity index, and reaction times), visual responses to appetitive cues (occipital P1, N1, and P2 components), and electrophysiological markers of conflict detection and response inhibition (frontal N2 and P3 waveforms). Under placebo, patients produced faster reaction times to alcohol-primed Go stimuli, an effect that was weak despite being statistically significant. However, the effect of alcoholic cues on the speed of response initiation disappeared after receiving nalmefene. We found no placebo versus nalmefene difference regarding our patients’ ability to accurately inhibit responses to NoGo stimuli or for occipital and frontal event-related potentials. Our results suggest that nalmefene might be potent in reducing the vigor to act upon alcoholic cues in AUD patients, but this effect is most probably mediated via subcortical (rather than cortical) neural circuits.en_US
dc.descriptionSource at <a href=https://doi.org/10.3389/fphar.2019.01087>https://doi.org/10.3389/fphar.2019.01087. </a> Copyright © 2019 Gál, Kilencz, Albert, Demeter, Hegedűs, Janka, Csifcsák and Álmos.en_US
dc.identifier.citationGál, B., Kilencz, T., Albert, A., Demeter, I., Hegedűs, K.M., Janka, Z. ... Álmos, P.Z. (2019). Mild Effect of Nalmefene on Alcoholic Cue-Induced Response Invigoration in Alcohol Use Disorder Without Accompanying Changes in Electrophysiological Signatures of Early Visual Processing and Executive Control. <i>Frontiers in Pharmacology, 10</i>: 1087. https://doi.org/10.3389/fphar.2019.01087en_US
dc.identifier.cristinIDFRIDAID 1744850
dc.identifier.doi10.3389/fphar.2019.01087
dc.identifier.issn1663-9812
dc.identifier.urihttps://hdl.handle.net/10037/16631
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Pharmacology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titleMild Effect of Nalmefene on Alcoholic Cue-Induced Response Invigoration in Alcohol Use Disorder Without Accompanying Changes in Electrophysiological Signatures of Early Visual Processing and Executive Controlen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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