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Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp.

Permanent link
https://hdl.handle.net/10037/16686
DOI
https://doi.org/10.3390/molecules24213991
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Date
2019-11-05
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Schneider, Yannik Karl-Heinz; Østnes Hansen, Kine; Isaksson, Johan; Ullsten-Wahlund, Sara Maria; Hansen, Espen; Andersen, Jeanette Hammer
Abstract
Two bacterial isolates from the Barents Sea, both belonging to the genus Algibacter, were found to yield extracts with anti-bacterial bioactivity. Mass spectrometry guided dereplication and purification of the active extracts lead to the isolation of the same active principle in both extracts. The structure of the bioactive compound was identified via mass spectrometry and nuclear resonance spectroscopy and it turned out to be the known lipopeptide Lipid 430. We discovered and determined its previously unknown anti-bacterial activity against Streptococcus agalactiae and revealed a cytotoxic effect against the A2058 human melanoma cell line at significantly lower concentrations compared to its anti-bacterial concentration. Flow cytometry and microscopy investigations of the cytotoxicity against the melanoma cell line indicated that Lipid 430 did not cause immediate cell lysis. The experiments with melanoma cells suggest that the compound functions trough more complex pathways than acting as a simple detergent.
Is part of
Schneider, Y.K.-H. (2020). Bioactive secondary metabolites from bacteria. Natural products from marine and terrestrial bacteria, dereplication, isolation and investigation of bacterial secondary metabolites. (Doctoral thesis). https://hdl.handle.net/10037/19264
Publisher
MDPI
Citation
Schneider, Y.K.H., Hansen, K.Ø., Isaksson, J., Ullsten, S., Hansen, E.H. & Andersen, J.H. (2019). Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp. Molecules, 24(21), 3991. https://doi.org/10.3390/molecules24213991
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