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dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.contributor.authorWirsing, Anna Maria
dc.date.accessioned2019-12-10T14:29:49Z
dc.date.available2019-12-10T14:29:49Z
dc.date.issued2019-02-27
dc.description.abstract<i>Background</i> - Various immune cells have been suggested as prognostic markers for cancer patients. In this article, we present a systematic review and meta-analysis of studies assessing the prognostic value of tissue-infiltrating immune cells in oral cancer and discuss the reporting quality of these studies.<p> <p><i>Methods</i> - We performed a systematic literature search and included studies using immunohistochemistry and survival analysis to assess the prognostic value of tumour-infiltrating T cells, B cells, macrophages, dendritic cells, mast cells and natural killer cells in oral cancer. We performed meta-analysis of studies providing necessary statistical data and investigated the studies’ adherence to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guidelines.<p> <p><i>Results</i> - Of the 1960 articles identified, 33 were eligible for this systematic review and 8 were included in the meta-analysis. CD163+ M2 macrophages and CD57+ natural killer cells were the most promising predictors of survival in oral cancer patients. Many studies lacked important information on their design and conduct.<p> <p><i>Conclusion</i> - Deficiencies in the reporting of study design and conduct make it difficult to draw reliable conclusions about the suggested markers. The prognostic value of CD163+ M2 macrophages and CD57+ natural killer cells should be validated in large, standardised studies.en_US
dc.identifier.citationHadler-Olsen ES, Wirsing AM. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. British Journal of Cancer. 2019;120(7):714-727en_US
dc.identifier.cristinIDFRIDAID 1704651
dc.identifier.doi10.1038/s41416-019-0409-6
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/16880
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofWirsing, A.M. (2018). The immune microenvironment in oral squamous cell carcinoma – characterization and prognostic markers. (Doctoral thesis). <a href=https://hdl.handle.net/10037/28606>https://hdl.handle.net/10037/28606</a>.
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleTissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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