Show simple item record

dc.contributor.authorSharashova, Ekaterina
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorBall, Jocasta
dc.contributor.authorMorseth, Bente
dc.contributor.authorGerdts, Eva
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorLøchen, Maja-Lisa
dc.date.accessioned2019-12-17T15:06:59Z
dc.date.available2019-12-17T15:06:59Z
dc.date.issued2019-05-03
dc.description.abstractAims To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population. Methods and results Blood pressure was measured in 8376 women and 7670 men who attended at least two of the three population-based Tromsø Study surveys conducted in 1986–87, 1994–95, and 2001. Participants were followed for incident AF throughout 2013. Latent mixed modelling was used to identify long-term trajectories of systolic BP and hypertension. Cox regression was used to estimate associations between the identified trajectories and incident AF. Elevated systolic BP throughout the exposure period (1986–2001) independently and differentially increased risk of AF in women and men. In women, having elevated systolic BP trajectories doubled AF risk compared to having persistently low levels, irrespective of whether systolic BP increased, decreased, or was persistently high over time, with hazard ratios of 1.88 (95% confidence interval 1.37–2.58), 2.32 (1.61–3.35), and 1.94 (1.28–2.94), respectively. In men, those with elevated systolic BP that continued to increase over time had a 50% increased AF risk: 1.51 (1.09–2.10). When compared to those persistently normotensive, women developing hypertension during the exposure period, and women and men with hypertension throughout the exposure period had 1.40 (1.06–1.86), 2.75 (1.99–3.80), and 1.36 (1.10–1.68) times increased risk of AF, respectively. Conclusion Long-term BP and hypertension trajectories were associated with increased incidence of AF in both women and men, but the associations were stronger in women.en_US
dc.identifier.citationSharashova EE, Wilsgaard T, Ball J, Morseth B, Gerdts E, Hopstock LA, Mathiesen EB, Schirmer H, Løchen M. Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study . European Heart Journal. 2019en_US
dc.identifier.cristinIDFRIDAID 1696231
dc.identifier.doi10.1093/eurheartj/ehz234
dc.identifier.issn0195-668X
dc.identifier.issn1522-9645
dc.identifier.urihttps://hdl.handle.net/10037/16962
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalEuropean Heart Journal
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright The Author(s).
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleLong-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record