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dc.contributor.authorRobertsen, Børre
dc.contributor.authorGreiner-Tollersrud, Linn
dc.contributor.authorJørgensen, Lars Gaute
dc.date.accessioned2020-01-31T12:15:47Z
dc.date.available2020-01-31T12:15:47Z
dc.date.issued2018-09-06
dc.description.abstractMx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. Analysis of the Atlantic salmon genome revealed the presence of 9 Mx genes localized to three chromosomes. A cluster of three Mx genes (SsaMx1 – SsaMx3), which includes previously cloned Mx genes, is present on chromosome (Chr) 12. A cluster of five Mx genes (SsaMx4-SsaMx8) is present on Chr25 while one Mx gene (SsaMx9) is present on Chr9. Phylogenetic and gene synteny analyses showed that SsaMx1-SsaMx3 are most closely related to the main group of teleost Mx proteins. In contrast, SsaMx 4-SsaMx9 formed a separate group together with zebrafish MxD and MxG and eel MxB. The Mx cluster in Chr25 showed gene synteny similar to a Mx gene cluster in the gar genome. Expression of Mx genes in cell lines stimulated with recombinant IFNs showed that Mx genes in Chr12 responded more strongly to type I IFN than to type II IFN (IFN gamma) whilst Mx genes in Chr25 responded more strongly to IFN gamma than to type I IFNs. SsaMx9 showed no response to the IFNs.en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a>en_US
dc.identifier.citationRobertsen B, Greiner-Tollersrud L, Jørgensen LG. Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN. Developmental and Comparative Immunology. 2019;90:80-89en_US
dc.identifier.cristinIDFRIDAID 1696604
dc.identifier.doi10.1016/j.dci.2018.09.004
dc.identifier.issn0145-305X
dc.identifier.issn1879-0089
dc.identifier.urihttps://hdl.handle.net/10037/17285
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalDevelopmental and Comparative Immunology
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2018 Elsevier Ltd. All rights reserved.en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.titleAnalysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFNen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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