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dc.contributor.authorGaustad, Svein Erik
dc.contributor.authorKondratyev, Timofey
dc.contributor.authorEftedal, Ingrid
dc.contributor.authorTveita, Torkjel
dc.date.accessioned2020-02-26T09:24:31Z
dc.date.available2020-02-26T09:24:31Z
dc.date.issued2020-01-13
dc.description.abstractCardiovascular risk is elevated in divers, but detailed information of cardiac function during diving is missing. The aim of this study was to apply an intact rat model with continuous monitoring of cardiac left ventricular (LV) function in a simulated diving experiment. Thirteen rats were inserted with a LV pressure–volume catheter and a pressure transducer in the femoral artery to measure hemodynamic variables, and randomly assigned to diving (<i>n</i> = 9) and control (<i>n</i> = 4) groups. The diving group was compressed to 600 kPa in air, maintained at pressure for 45 min (bottom phase), and decompressed to surface at 50 kPa/min. Data was collected before, during, and up to 60 min after exposure in the diving group, and at similar times in non-diving controls. During the bottom phase, stroke volume (SV) (−29%) and cardiac output (−30%) decreased, whereas LV end-systolic volume (+13%), mean arterial pressure (MAP) (+29%), and total peripheral resistance (TPR) (+72%) increased. There were no changes in LV contractility, stroke work, or diastolic function. All hemodynamic variables returned to baseline values within 60 min after diving. In conclusion, our simulated dive experiment to 600 kPa increased MAP and TPR to levels which caused a substantial reduction in SV and LV volume output. The increase in cardiac afterload demonstrated to take place during a dive is well tolerated by the healthy heart in our model, whereas in a failing heart this abrupt change in afterload may lead to acute cardiac decompensation.en_US
dc.identifier.citationGaustad SE, Kondratyev T.V., Eftedal I, Tveita T. Continuous hemodynamic monitoring in an intact rat model of simulated diving. Frontiers in Physiology. 2020en_US
dc.identifier.cristinIDFRIDAID 1744811
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/10037/17509
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Physiology
dc.relation.projectIDNorges forskningsråd: 280425en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/PETROMAKS2/280425/Norway/Dealing with depths: systems biology of health preservation in professional saturation diving//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleContinuous hemodynamic monitoring in an intact rat model of simulated divingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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