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dc.contributor.authorŠtšepetova, Jelena
dc.contributor.authorTruu, Jaak
dc.contributor.authorRunnel, Riina
dc.contributor.authorNõmmela, Rita
dc.contributor.authorSaag, Mare
dc.contributor.authorOlak, Jaana
dc.contributor.authorNõlvak, Hiie
dc.contributor.authorPreem, Jens-Konrad
dc.contributor.authorOopkaup, Kristjan
dc.contributor.authorKrjutškov, Kaarel
dc.contributor.authorHonkala, Eino
dc.contributor.authorHonkala, Sisko
dc.contributor.authorMäkinen, Kauko
dc.contributor.authorMäkinen, Pirkko-Liisa
dc.contributor.authorVahlberg, Tero
dc.contributor.authorVermeiren, Joan
dc.contributor.authorBosscher, Douwina
dc.contributor.authorde Cock, Peter
dc.contributor.authorMändar, Reet
dc.date.accessioned2020-02-27T07:29:13Z
dc.date.available2020-02-27T07:29:13Z
dc.date.issued2019-04-18
dc.description.abstract<i>Background</i> - Oral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome.<p><p> <i>Methods</i> - Ninety children (11.3 ± 0.6 years) consumed candies during 3 years. Microbial communities were profiled using Illumina HiSeq 2000 sequencing and real-time PCR.<p><p> <i>Results</i> - The dominant phyla in saliva were <i>Firmicutes</i> (39.1%), <i>Proteobacteria</i> (26.1%), <i>Bacteroidetes</i> (14.7%), <i>Actinobacteria</i> (12%) and <i>Fusobacteria</i> (6%). The microbiome of erythritol group significantly differed from that of the other groups. Both erythritol and xylitol reduced the number of observed bacterial phylotypes in comparison to the control group. The relative abundance of the genera <i>Veillonella</i>, <i>Streptococcus</i> and <i>Fusobacterium</i> were higher while that of <i>Bergeyella</i> lower after erythritol intervention when comparing with control. The lowest prevalence of caries-related mutans streptococci corresponded with the lowest clinical caries markers in the erythritol group.<p><p> <i>Conclusions</i> - Daily consumption of erythritol, xylitol or control candies has a specific influence on the salivary microbiome composition in schoolchildren. Erythritol is associated with the lowest prevalence of caries-related mutans streptococci and the lowest levels of clinical caries experience.en_US
dc.identifier.citationŠtšepetova, Truu J, Runnel R, Nõmmela, Saag M, Olak J, Nõlvak, Preem, Oopkaup, Krjutškov, Honkala EJ, Honkala S, Mäkinen, Mäkinen, Vahlberg T, Vermeiren J, Bosscher, de Cock P, Mändar R. Impact of polyols on oral microbiome of Estonian schoolchildren. BMC Oral Health. 2019;19:60:1-10en_US
dc.identifier.cristinIDFRIDAID 1797042
dc.identifier.doi10.1186/s12903-019-0747-z
dc.identifier.issn1472-6831
dc.identifier.urihttps://hdl.handle.net/10037/17521
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Oral Health
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical dentistry disciplines: 830en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830en_US
dc.titleImpact of polyols on oral microbiome of Estonian schoolchildrenen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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