Show simple item record

dc.contributor.authorUeland, Thor
dc.contributor.authorRoland, Marie Cecilie
dc.contributor.authorMichelsen, Annika
dc.contributor.authorGodang, Kristin
dc.contributor.authorAukrust, Pål
dc.contributor.authorHenriksen, Tore
dc.contributor.authorBollerslev, Jens
dc.contributor.authorLekva, Tove
dc.date.accessioned2020-02-27T12:26:58Z
dc.date.available2020-02-27T12:26:58Z
dc.date.issued2019-10-29
dc.description.abstract<i>Context</i> - Cholesteryl ester transfer protein (CETP) regulates high-density lipoprotein (HDL) cholesterol levels and interaction between glucose, and HDL metabolism is central in the development of diabetes.<p> <p><i>Objective</i> - We hypothesized that CETP levels would be regulated in diabetic pregnancies. We tested the hypothesis by evaluating CETP activity measured multiple times during pregnancy and at 5 years’ follow-up in a prospective cohort (STORK) and investigated its association with gestational diabetes mellitus (GDM) during pregnancy or development of prediabetes 5 years after pregnancy. We also evaluated the strongest correlation of CETP activity among measures of adipocity and glucose metabolism, lipoproteins, adipokines, and monocyte/macrophage activation markers.<p> <p><i>Design</i> - A population-based longitudinal cohort study was conducted from 2001 to 2013.<p> <p><i>Setting</i> - The study setting was Oslo University Hospital.<p> <p><i>Patients or Other Participants</i> - A total of 300 women during pregnancy and at 5 years postpartum participated in this study.<p> <p><i>Main Outcome Measures</i> - CETP activity was measured at 14 to 16, 22 to 24, 30 to 32, and 36 to 38 weeks’ gestation, and at 5 years’ follow-up.<p> <p><i>Results</i> - We found higher CETP activity in pregnancy in women developing prediabetes but no association with GDM. CETP activity decreased throughout pregnancy and remained low at follow-up. High CETP activity was associated with sCD14 levels, in particular in women who developed prediabetes. These data show that enhanced CETP activity during pregnancy is associated with systemic indices of monocyte/macrophage activation, in particular in women who develop prediabetes later in life.<p> <p><i>Conclusions</i> - CETP activity during pregnancy identifies women at risk for later diabetes development.en_US
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in JCEM following peer review. The version of record Ueland, T., Roland, M.C.P., Michelsen, A.E., Godang, K., Aukrust, P., Henriksen, T. ... Lekva, T. (2019). Elevated Cholesteryl Ester Transfer Protein Activity Early in Pregnancy Predicts Prediabetes 5 Years Later. <i>The Journal of Clinical Endocrinology & Metabolism, 105</i>(3), is available online at: https://doi.org/10.1210/clinem/dgz119.en_US
dc.identifier.citationUeland T, Roland MCP, Michelsen A, Godang K, Aukrust P, Henriksen T, Bollerslev J, Lekva T. Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later. Journal of Clinical Endocrinology and Metabolism. 2019en_US
dc.identifier.cristinIDFRIDAID 1793451
dc.identifier.doi10.1210/clinem/dgz119
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.urihttps://hdl.handle.net/10037/17536
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalJournal of Clinical Endocrinology and Metabolism
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© Endocrine Society 2019. All rights reserved.en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleElevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years lateren_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record