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Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model

Permanent link
https://hdl.handle.net/10037/17916
DOI
https://doi.org/10.1016/j.transci.2019.102711
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Date
2019-12-31
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Tiller, Heidi; Ahlen, Maria Therese; Akkøk, Cigdem Ahaein; Husebekk, Anne
Abstract
In Norway, the management strategy for fetal and neonatal alloimmune thrombocytopenia (FNAIT) has for more than two decades differed from most other countries. The focus of this paper is to describe and discuss the Norwegian FNAIT management program. We recommend antenatal IVIg to women who previously have had a child with FNAIT-induced ICH, and usually not to HPA-1a alloimmunized pregnant women where a previous child had FNAIT, but not ICH. When deciding management strategy, we use not only the obstetric history but also the antenatal anti-HPA-1a antibody level as a tool for risk stratification. The Norwegian National Unit for Platelet Immunology (NNUPI) at the University Hospital of North Norway in Tromsø provides diagnostic and consulting service for the clinicians and the blood banks all over the country, and serves as a national reference laboratory for FNAIT investigations.
Publisher
Elsevier
Citation
Tiller H, Husebekk A, Ahlen MT, Akkøk CA. Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model. Transfusion and Apheresis Science. 2019
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
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