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dc.contributor.authorSejrup, Joakim Knutsen
dc.contributor.authorBørvik, Trond
dc.contributor.authorGrimnes, Gro
dc.contributor.authorIsaksen, Trond
dc.contributor.authorHindberg, Kristian
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorMorelli, Vania Maris
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.date.accessioned2020-03-31T07:46:45Z
dc.date.available2020-03-31T07:46:45Z
dc.date.issued2019-06-16
dc.description.abstractPatients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the fourth survey of the Tromsø Study. VTE risk factors and hospitalizations were registered during the 90-day period preceding the VTE diagnosis (hazard period) and in four 90-day control periods. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE according to acute MI and after adjustment for other risk factors. Additionally, we applied a mediation analysis to quantify how much the known transient risk factors account for the observed effect of MI on VTE risk. MI was recorded in 13 (1.8%) of the hazard periods and in 6 (0.2%) of the control periods, which yielded a crude OR of 11.9 (95% CI: 3.9–36.7). Adjustment for immobilization and infection yielded an OR of 2.7 (95% CI: 0.6–11.2). The OR was attenuated to 2.6 (95% CI: 0.6–11.9) after further adjustment for major surgery, trauma, red blood cell transfusion, and central venous catheterization. Approximately 60% of the association between MI and VTE was mediated through infection and immobilization. In conclusion, our findings suggest that the increased VTE risk after MI may to a large extent be explained by concomitant conditions related to MI, particularly infections and immobilization.en_US
dc.identifier.citationSejrup JK, Børvik T, Grimnes G, Isaksen T, Hindberg K, Hansen JB, Morelli VM, Brækkan SK. Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study. Thrombosis and Haemostasis. 2019;119(8):1358-1364en_US
dc.identifier.cristinIDFRIDAID 1709292
dc.identifier.doi10.1055/s-0039-1692176
dc.identifier.issn0340-6245
dc.identifier.urihttps://hdl.handle.net/10037/17930
dc.language.isoengen_US
dc.publisherThieme Publishingen_US
dc.relation.ispartofSejrup, J.K. (2022). Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction. (Doctoral thesis). <a href=https://hdl.handle.net/10037/25377>https://hdl.handle.net/10037/25377</a>.
dc.relation.journalThrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2019, Rights Managed by Georg Thieme Verlag KG Stuttgart • New Yorken_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleMyocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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