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Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice

Permanent lenke
https://hdl.handle.net/10037/18212
DOI
https://doi.org/10.1152/ajpheart.00191.2019
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article.pdf (512.9Kb)
Akseptert manusversjon (PDF)
Dato
2019-07-16
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Jansen, Kirsten; Moreno, Sonia; Garcia-Roves, Pablo M; Larsen, Terje
Sammendrag
The aim of this study was to find out whether dietary supplementation with Calanus oil (a novel marine oil) or infusion of exenatide (an incretin mimetic) could counteract obesity-induced alterations in myocardial metabolism and improve postischemic recovery of left ventricular (LV) function. Female C57bl/6J mice received high-fat diet (HFD, 45% energy from fat) for 12 wk followed by 8-wk feeding with nonsupplemented HFD, HFD supplemented with 2% Calanus oil, or HFD plus exenatide infusion (10 µg·kg−1·day−1). A lean control group was included, receiving normal chow throughout the whole period. Fatty acid and glucose oxidation was measured in ex vivo perfused hearts during baseline conditions, while LV function was assessed with an intraventricular fluid-filled balloon before and after 20 min of global ischemia. HFD-fed mice receiving Calanus oil or exenatide showed less intra-abdominal fat deposition than mice receiving nonsupplemented HFD. Both treatments prevented the HFD-induced decline in myocardial glucose oxidation. Somewhat surprising, recovery of LV function was apparently better in hearts from mice fed nonsupplemented HFD relative to hearts from mice fed normal chow. More importantly however, postischemic recovery of hearts from mice receiving HFD with Calanus oil was superior to that of mice receiving nonsupplemented HFD and mice receiving HFD with exenatide, as expressed by better pressure development, contractility, and relaxation properties. In summary, dietary Calanus oil and administration of exenatide counteracted obesity-induced derangements of myocardial metabolism. Calanus oil also protected the heart from ischemia, which could have implications for the prevention of obesity-related cardiac disease.
Er en del av
Jansen, K.M. (2021). Modulation of Cardiometabolic Health by Dietary Supplementation with Calanus oil. (Doctoral thesis). https://hdl.handle.net/10037/22254.
Forlag
American Physiological Society
Sitering
Jansen, K; Moreno, S.; Garcia-Roves, P.M.; Larsen, T.(2019) Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice. American Journal of Physiology. Heart and Circulatory Physiology, 317,(2), H290-H299
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  • Artikler, rapporter og annet (medisinsk biologi) [1103]
Copyright © 2019 the American Physiological Society

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