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dc.contributor.authorPihl, Kasper
dc.contributor.authorSørensen, Steen
dc.contributor.authorNystad, Mona
dc.contributor.authorAcharya, Ganesh
dc.contributor.authorJørgensen, Finn S.
dc.date.accessioned2020-05-28T07:01:22Z
dc.date.available2020-05-28T07:01:22Z
dc.date.issued2018-04-22
dc.description.abstract<i>Objective</i>: The aim of this study was to compare the laeverin level in maternal serum from first trimester (11–14 weeks) of pregnancy between normal pregnancies and pregnancies that later developed preeclampsia (PE).<p><p> <i>Material and methods</i>: This was a case-cohort study. The laeverin concentration was measured in cases with preterm PE (<i>n</i> = 55), term PE (<i>n</i> = 95), and a reference group of randomly selected women with normal pregnancy outcome (<i>n</i> = 200) in stored serum samples collected from the double-test as part of the combined first trimester trisomy 21 screening program. The samples were thawed and analyzed for laeverin. The median gestational age at blood sampling was 77 days (range 57–96 days). Multiple regression analysis was performed to establish a normal median. Concentrations were converted to multiples of the median (MoM) and groups were compared using the Mann–Whitney U-test.<p><p> <i>Results</i>: In the reference group, laeverin was significantly correlated with gestational age (<i>r</i> = 0.18, <i>p</i> = .01) and its concentration ranged from 41–393 µg/L. No significant differences in the median laeverin MoM were found between the reference group (1.01 MoM) and cases with preterm PE (0.98 MoM) or term PE (0.96 MoM).<p><p> <i>Conclusions</i>: First trimester maternal serum laeverin level cannot be used to predict preeclampsia.en_US
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Maternal-Fetal and Neonatal Medicine on 22 Apr 2018, available online: http://www.tandfonline.com/<a href=https://doi.org/10.1080/14767058.2018.1463368>https://doi.org/10.1080/14767058.2018.1463368</a>.en_US
dc.identifier.citationPihl, Sørensen, Nystad M, Acharya G, Jørgensen. Maternal serum laeverin (aminopeptidase Q) measured in the first trimester of pregnancy does not predict preeclampsia. Journal of Maternal-Fetal & Neonatal Medicine. 2019;32(20):3348-3351en_US
dc.identifier.cristinIDFRIDAID 1717522
dc.identifier.doi10.1080/14767058.2018.1463368
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.urihttps://hdl.handle.net/10037/18393
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalJournal of Maternal-Fetal & Neonatal Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2018 Informa UK Limited, trading as Taylor & Francis Groupen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleMaternal serum laeverin (aminopeptidase Q) measured in the first trimester of pregnancy does not predict preeclampsiaen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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