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dc.contributor.authorThoen, Even
dc.contributor.authorTartor, Haitham
dc.contributor.authorAmundsen, Marit
dc.contributor.authorDale, Ole Bendik
dc.contributor.authorSveinsson, Karoline Overn
dc.contributor.authorRønning, Hans Petter
dc.contributor.authorGrønneberg, Estelle
dc.contributor.authorDahle, Maria
dc.contributor.authorGjessing, Mona Cecilie
dc.date.accessioned2020-06-11T10:33:16Z
dc.date.available2020-06-11T10:33:16Z
dc.date.issued2020-05-07
dc.description.abstractSalmon gill poxvirus (SGPV) infection is a common denominator in many cases of complex gill disease in the Norwegian salmon farming industry and may, as a single agent infection, result in salmon poxvirus disease (SGPVD). Experiences from the field suggest that stress may be a decisive factor for the induction of SGPVD. Here we investigated the effect of stress hormone treatment on SGPV kinetics and disease development. In our experiment, Atlantic salmon were divided into four groups. Two groups of fish received an intraperitoneal injection of hydrocortisone dissolved in a fatty vehicle, whereas fish in the other two groups received a sham injection of the vehicle. After 24 h, one group with hydrocortisone injection and one with sham injection were exposed to dead SGPV-infected fish. Plasma cortisol level, virus kinetics, virus localization, and pathological gill were monitored for 4 weeks post-exposure. Hydrocortisone injected fish displayed higher plasma cortisol and SGPV loads than non-hydrocortisone treated fish. Signs of SGPVD and ensuing mortality appeared only in fish exposed to the virus and injected with hydrocortisone around 2 weeks post-exposure. No clinical signs of disease or mortality were recorded in the other groups. Further, gill histopathology in diseased fish correlated well with SGPV load, with the infection apparently confined to gill epithelial cells. The current findings suggest elevated plasma cortisol being a prerequisite for the development of SGPVD and recommend minimization of stressful farming activities, particularly if SGPV infection has been previously identified.en_US
dc.identifier.citationThoen E, Tartor HM, Amundsen M, Dale OB, Sveinsson KO, Hans Petter, Grønneberg E, Dahle MK, Gjessing MCG. First record of experimentally induced salmon gill poxvirus disease (SGPVD) in Atlantic salmon (Salmo salar L.). Veterinary research (VR). 2020;51(63)en_US
dc.identifier.cristinIDFRIDAID 1808709
dc.identifier.doihttps://doi.org/10.1186/s13567-020-00787-9
dc.identifier.issn0928-4249
dc.identifier.issn1297-9716
dc.identifier.urihttps://hdl.handle.net/10037/18522
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalVeterinary research (VR)
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/267491/Norway/Understanding Salmon gill poxvirus disease; an emerging threat for Atlantic salmon farming//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.titleFirst record of experimentally induced salmon gill poxvirus disease (SGPVD) in Atlantic salmon (Salmo salar L.)en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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