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dc.contributor.authorZmeykina, E
dc.contributor.authorMittner, Matthias
dc.contributor.authorPaulus, Walter
dc.contributor.authorTuri, Zsolt
dc.date.accessioned2020-08-11T11:43:07Z
dc.date.available2020-08-11T11:43:07Z
dc.date.issued2020-07-20
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) is a potent tool for modulating endogenous oscillations in humans. The current standard method for rTMS defines the stimulation intensity based on the evoked liminal response in the visual or motor system (e.g., resting motor threshold). The key limitation of the current approach is that the magnitude of the resulting electric field remains elusive. A better characterization of the electric field strength induced by a given rTMS protocol is necessary in order to improve the understanding of the neural mechanisms of rTMS. In this study we used a novel approach, in which individualized prospective computational modeling of the induced electric field guided the choice of stimulation intensity. We consistently found that rhythmic rTMS protocols increased neural synchronization in the posterior alpha frequency band when measured simultaneously with scalp electroencephalography. We observed this effect already at electric field strengths of roughly half the lowest conventional field strength, which is 80% of the resting motor threshold. We conclude that rTMS can induce immediate electrophysiological effects at much weaker electric field strengths than previously thought.en_US
dc.identifier.citationZmeykina, Mittner M, Paulus W, Turi Z. Weak rTMS-induced electric fields produce neural entrainment in humans. Scientific Reports. 2020en_US
dc.identifier.cristinIDFRIDAID 1822631
dc.identifier.doihttps://doi.org/10.1038/s41598-020-68687-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/18951
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titleWeak rTMS-induced electric fields produce neural entrainment in humansen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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