Blar i tittel Mastergradsoppgaver i farmasi

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    • Design and synthesis of novel cyclopentapeptide antagonist for the chemokine receptor CXCR4 

      Eriksen, Øystein (Master thesis; Mastergradsoppgave, 2008-06-16)
      CXCR4 is a GPCR that by activation of its ligand CXCL12 is involved in the pathology of several diseases, examples being cancer and rheumatoid arthritis. It has also shown to play a crucial role for HIV-1 entry into T-cells and the development of AIDS. Several cyclopentapeptides (CPPs) based on the sequence D-Tyr-Arg-Arg-2-Nal-Gly of the lead compound FC131 have shown to have antagonistic activity. ...

    • Design og syntese av cyklopentapeptidbaserte CXCR4 antagonister: Variasjon av essensiell aromatisk substituent 

      Aune, Jon Åge (Mastergradsoppgave; Master thesis, 2009-05-20)
      SAMMENDRAG CXCR4 er en kjemokinreseptor som er involvert i en rekke biologiske prosesser i kroppen, blant annet angiogenese, neurogenese og dannelse av blodceller i embryostadiet. I voksne er CXCR4 funnet å være involvert i sykdommer som HIV, reumatoid artritt og kreft. I litteraturen finnes det potente CXCR4 antagonister (AMD3100, KRH1636, FC131) som har vist effekt mot HIV-1, reumatoid artritt ...

    • Design, synthesis and structural studies of relaxin receptor modulators 

      Elvheim, Iselin Sørstad (Master thesis; Mastergradsoppgave, 2011-06)
      The relaxin family of peptides consists of seven structurally related peptides, with a wide variety of biological functions, ranging from involvement in reproductive processes to functions as neuroendocrine modulators. Because of the complex, two-chained structure of the relaxins, and their lack of specificity for the various relaxin family receptors (RXFPs), design of simpler, more selective ...

    • Det metastaseassosierte proteinet S100A4 i orale plateepitelkarsinomcellelinjer - kartlegging av effekter på proteolytiske enzymer viktige for invasjon og metastase 

      Skretting, Trine (Master thesis; Mastergradsoppgave, 2012-05-20)
      Oralkreft er en kreftform forbundet med dårlig prognose, som hovedsakelig skyldes hyppig forekomst av lokal invasjon og metastase til lymfeknuter. Behandlingen består i dag hovedsakelig av kirurgi og stråling, men på tross av stadig nye og bedre behandlingsformer er mortaliteten for pasienter med oralkreft uendret de siste 30 årene. Med den vedvarende høye dødsraten av oralkreft er det et tydelig ...

    • Determination of Cysteine Connectivity in Bioactive Peptides 

      Moen, Merete Kveli (Master thesis; Mastergradsoppgave, 2014-05-20)
      Conotoxins are diverse and well-studied, and is therefore suited as a model to develop a general method for analyzing disulfide-rich peptides. To investigate the folding of both commercially available and self-synthesized Conotoxins, an UHPLC-MS/MS method was developed where one disulfide-bridge was reduced at the time and alkylated with different maleimides. The results from the UHPLC-MS/MS method ...

    • Developement of mucoadhesive polymer-coated liposomes for hydration of the oral mucosa 

      Saleh, Rebwar Salar Nori (Master thesis; Mastergradsoppgave, 2013-05-18)
      Dry mucus in the oral cavity is uncomfortable for patients and can lead to other additional illnesses. Reduced or absence of saliva secretion, caused by the diseases, side effects of drugs, aging, or radiotherapy, can result in issues related to xerostomia and dental health. A system that could contribute to increased hydration of the mucus would reduce the discomfort for the patient. In addition, ...

    • Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates 

      Valla, Sanne Ekroll (Master thesis; Mastergradsoppgave, 2017-05-15)
      Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ...

    • The Development of a pharmaceutical care plan in the Scottish mental health service 

      Skarsaune, Mona (Master thesis; Mastergradsoppgave, 2008-06)
      Abstract Background Pharmaceutical care planning is increasingly seen as the most effective manner by which to deliver pharmaceutical care services to the patient. The role of the pharmacist, both specialist and generalist, is paramount, as much of the treatment in Mental Health is dependent on the effective management of the patients medication(1). Consequently, there is a need for standardised ...

    • Development of an analytical method for detection and quantification of cannabis and cannabinoid analogues in urine 

      Steinshamn, Eirin Berge (Master thesis; Mastergradsoppgave, 2010-05-20)
      Cannabis is a drug mainly consumed for its euphoric effects; users may become happy, careless and relaxed. The direct effects of cannabis in sports are performance decreasing, but cannabis can be used as a doping agent due to its relaxing properties. For these reasons, cannabinoids are prohibited in sports during competition by the World Anti-Doping Agency (WADA). In the context of the fight ...

    • Development of an in vitro model to study compromised skin: pigskin versus the Phospholipid Vesicle-based Permeation Assay 

      Fedreheim, Elena (Master thesis; Mastergradsoppgave, 2013-05-20)
      When the skin barrier is reduced, penetration of topical and transdermal drugs could potentially be enhanced and the risk of systemic effects is increased. The studies analysing penetration through intact or diseased skin are often limited by the variability in obtaining specimens of representative skin. The phospholipid vesicle-based permeation assay is an artificial barrier mimicking human stratum ...

    • Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases 

      Baumann, Markus (Master thesis; Mastergradsoppgave, 2012-06)
      Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ...

    • Development of chitosan-coated liposomes for improved therapy of vaginal infections: clotrimazole as model drug 

      Jøraholmen, May Wenche Bakke (Master thesis; Mastergradsoppgave, 2012-05)
      For many drugs the vaginal route of administration is favorable, particularly for local therapy of specific gynecological diseases such as vaginal infections. A large variety of pharmaceutical preparations have been developed for vaginal delivery, nevertheless, the efficiency of currently available dosage forms is often limited by their poor retention time at the vaginal site. Physiological changes ...

    • Development of COFRADIC HPLC system for proteomics. Sorting of N-terminal peptides 

      Banki, Maryam Ghazi Ali (Master thesis; Mastergradsoppgave, 2014-05-20)
      Proteomics, the study of the proteins constituting the proteome, has featured in the past few years as an essential tool in a number of diverse areas of therapeutic research for detection of the initial stage of a disease, for consideration of therapy response and for disintegrating fundamental pathophysiological mechanisms. Proteomics has a wide range of applications such as diabetes research, ...

    • The development of electrospun chloramphenicol containing wound dressing 

      Murugaiah, Anjanah (Master thesis; Mastergradsoppgave, 2021-05-11)
      Wound healing is among the most complex processes in the human body that is greatly coordinated with a focus to rebuild tissue integrity and restore the skin´s protective barrier. The normal healing process is disrupted in chronic wounds, leading to delayed wound healing due to several underlying factors such as aging, obesity, and diabetes. Among chronic wounds 50 % are infected and up to 78 % of ...

    • Development of improved bendamustin-liposomes 

      Evjen, Tove Julie (Master thesis; Mastergradsoppgave, 2007-05)
      Bendamustin is an alkylating anticancer agent which is currently in routine use for the treatment of different types of cancer. The drug is very unstable in serum due to hydrolysis; the half life of the first part of the serum elimination curve is about 6-10 minutes. The rapid degradation of the drug in serum impairs its cytostatic action within a short period of time, and frequent application of ...

    • Development of liposomal curcumin for vaginal drug delivery 

      Hussain, Haider (Master thesis; Mastergradsoppgave, 2010-06-16)
      Curcumin (I), demethoxy curcumin (II) and bisdemethoxy curcumin (III) are commonly called curcuminoids, and derived products from the spice, turmeric. It has reported numerous of therapeutic activities including, anti-inflammatory, and anticancer properties. The aim of the current study was to develop a formulation which can overcome the limitation of curcumin being so poorly soluble in aqueous ...

    • Development of liposomal formulation for green tea catechins targeted for the treatment of vaginal inflammation 

      Trønnes, Johanne Naper (Master thesis; Mastergradsoppgave, 2012-05-20)
      Green tea catechins are well known for their antioxidative and anti-inflammatory properties. In this connection, catechins are thought to be potential candidates in prevention and treatment of diseases caused by oxidative damage. In addition, catechins have been shown to be effective in the treatment of genital warts. However, they exhibit low bioavailability and poor solubility, which limits their ...

    • Development of muds for improved vaginal therapy 

      Meland, Hilde-Gunn (Master thesis; Mastergradsoppgave, 2011-06-01)
      Bacterial vaginosis is a common cause of vaginitis, condition often treated with oral metronidazole. However, due to unpleasant side effects, patient compliance is often reduced. Vaginal tablet with bioadhesive properties could enable a prolonged residence time and a sustained release of a drug at the site of infection. Vagina as a drug administration site is attractive due to high surface area, ...

    • Development of orodispersible films: A new age-appropriate dosage form for children 

      Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
      In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...

    • Development of sample preparation methods for shotgun proteomic studies of white adipose tissue 

      Colnoe, Sayda (Master thesis; Mastergradsoppgave, 2016-05-13)
      Due to the lack of sunlight during the winter, people living in the arctic are unable to produce vitamin D3; hence deficiency of such vitamin is common in this part of the world. Given the geographic location of Norway, development of vitamin D deficiency is a common phenomenon. As vitamin D deficiency has become a public health issue, understanding the effects is vital for clinical implications. ...