Sammendrag Bakgrunn På grunn av sitt smale terapeutiske vindu har warfarin et stort interaksjonspotensiale med både mat og andre legemidler, noe som kan øke risikoen for blødninger. Det er kjent at uselektive NSAIDs kan interagere med warfarin, men også tilfeller med økt INR og blødninger ved bruk av andre smertestillende legemidler som paracetamol og tramadol er observert. Formål: Beskrive ...

In 2010, there were 2839 women and 13 men diagnosed with breast cancer in Norway, which was equivalent to an increase of almost 50% since 1956. The risk of developing breast cancer increases with age, and will affect one in ten women during their lifetime. Despite a substantial increase in the number of early-stage breast cancers detected due to screening-programs, there is still a need for new and ...

Bakgrunn: Bruken av kosttilskudd i Norge har hatt en økning over de siste 20 årene, og man har liten oversikt over forbruket. Det har kommet fram av flere amerikanske studier at bruken av kosttilskudd varierer med enkelte sosioøkonomiske variabler, som at kvinner med høyskoleutdannelse bruker mer kosttilskudd enn kvinner med lavere utdannelse. Det er også vist at forbruket av kosttilskudd er høyere ...

In the past few decades there has been an increasing awareness of pharmaceuticals in the environment and pharmaceuticals as environmental pollutants. Pharmaceuticals find their way to the aquatic environment mostly through sewage treatment plants. The potential toxicity of pharmaceuticals is of great interest as they have been discovered in air, water, soil, sediment and biota. The aim of the ...

Conotoxins are small disulfide rich peptides derived from the venom of Cone snails. They target different receptors in the nervous system with high selectivity and potency making them valuable as drug leads or drug themselves. One group of conotoxins, α-conotoxins have been shown to have potential as treatment for neuropathic pain.

Innledning: Apotekloven slår fast at legemidler skal utleveres nøyaktig etter resept og rekvisisjon. Studier viser imidlertid at feil og mangler forekommer ved 2,0 % av reseptene som blir levert inn ved vanlige apotek i Norge, og forskrivningsavvik forekommer ved 8,5 % av ordinasjonene på resepter utskrevet av leger ved Haukeland Universitetssykehus. Forskrivningsavvik kan medføre fare for klinisk ...

Autophagy is an essential cellular process that is important to maintain homeostasis by degrading proteins, lipids and organelles during critical times like cellular or environmental stress conditions. Autophagy plays a critical role in human pathologies, since defective autophagy can lead to diseases like cancer, neurodegenerative- and inflammatory diseases. Fez1 (Fasciculation and elongation protein ...

Introduction — The aim of Edinburgh Improved Anticipatory Care and Treatment (IMPACT) service is to reduce admissions and re-admissions to hospital for people with LTCs. The service consists of nurse case managers co-ordinating patients’ care, including reviewing medication. As a pilot project, an arrangement was made to refer such patients to a team of primary care pharmacists for clinical medication ...

Introduction There is little data on immuno-suppressant administration and prescribing to transplant patients. It was considered a high risk area because errors in prescribing and administration of immuno-suppressants can potentially have serious consequences like graft loss, side effects and even death. The reality was however that the lack of data meant that no one knew whether this was an area ...

BACKGROUND: Denosumab is a medication for postmenopausal osteoporosis delivered as a subcutaneous injection. Within the National Health Service (NHS) Lothian, Scotland, the treatment is currently administered in a hospital setting. Feedback from patients and staff indicate that the drug could most likely be delivered in a community setting, which is in accordance with Scottish Government policy ...