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norskBlar i tittel Mastergradsoppgaver i farmasi
Viser treff 201-220 av 283
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Mass Spectrometry Based Metabolomic and Lipidomic Analyses of Algal Biomass.
(Mastergradsoppgave; Master thesis, 2023-05-14)Background: In a project at UiT - the Arctic University of Norway, the lipid profile of the microalgal biomass from the specie Porosira glacialis is mapped using HRMS lipidomic analyses to evaluate the potential for the biomass to be used as fish feed. At the same time, it is desired to screen the same biomass for bioactivities using bioassays in combination with HRMS metabolomic analyses. ... -
Medication Assessment Tool for evaluering av antibiotikabehandling for pasienter med samfunnservervet pneumoni (MAT-CAP) i sykehus. Oppdatering, videreutvikling og applisering
(Master thesis; Mastergradsoppgave, 2015-05-13)Bakgrunn: Medication Assessment Tool (MAT) er et verktøy som brukes for undersøke hvorvidt forskrivning av legemidler er i henhold til kliniske retningslinjer. Et MAT for å undersøke behandling av CAP (MAT-CAP) ble utviklet i 2009 basert på lokale og internasjonale retningslinjer. I 2013 ble det i Norge publisert en nasjonal retningslinje for bruk av antibiotika i sykehus. Formål: å oppdatere og ... -
Melt processability of amorphous solid dispersions during hot-melt extrusion. Screening using vacuum compression moulding and evaluation by rheology and solid-state analysis
(Master thesis; Mastergradsoppgave, 2018-05-15)Soluplus is a suitable excipient for innovative manufacturing techniques such as hot-melt extrusion (HME). While Soluplus is useful for forming amorphous solid dispersions (ASD’s) during HME, the resulting extrudates are often stiff and brittle. In order to achieve suitable dosage forms, with optimal downstream processability, an efficient screening for suitable formulations is required. Vacuum ... -
Mercaptoalkanol-derived self-immolative linkers for bioconjugates. Synthesis and analysis
(Master thesis; Mastergradsoppgave, 2021-01-11)Many of the anticancer compounds discovered through synthesis or bioprospecting activities are found to be equally toxic to healthy cells and tumors. Consequently, these compounds are not considered as promising drug candidates worthy of further study. This project seeks to develop a novel chemical toolkit that can be utilized to increase the therapeutic value of such toxic compounds by decreasing ... -
Metabolic profiling of marine sponges as a tool to discover novel natural products
(Master thesis; Mastergradsoppgave, 2014-05-20)In this project metabolic profiling was explored as a means for finding unique and novel natural products. Natural products have had a vital role in drug discovery throughout history and in recent times, that includes the world oceans more and more. Therefore two related species of marine sponges, where the samples were collected from different locations, was chosen to test the methodology. This ... -
Metodeutvikling og innledende kompatibilitetsstudie mellom antiinfektiva og Olimel N5E gjennom Y-sett infusjon til barn fra 10 - 50 kg
(Master thesis; Mastergradsoppgave, 2011-06)Total parenteral ernæring (TPN) gis forebyggende eller korrigerende mot feilernæring til pasienter hvor oral eller enteral ernæring vanskelig lar seg gjøre. TPN inneholder glukose, fett og aminorsyrer i tillegg til viktige vitaminer, sporelementer og elektrolytter. TPN er en steril olje-i-vann (o/v) emulsjon, stabilisert ved hjelp av en lecitin-emulgator. Scenario hvor legemiddel og TPN må administreres ... -
Microfluidized liposomes for cellular uptake imaging: Optimization
(Mastergradsoppgave; Master thesis, 2020-05-14)Liposomes as drug delivery systems exhibit great potential to deliver active molecules to the targeted site depending on their various characteristics. However, these characteristics are dependent on the manufacturing procedures applied to prepare liposomes. Especially difficult is assurance of reproducible production in large volumes. Therefore an efficient up-scalable method for production of ... -
Modeling of glutamatergic and GABAergic drug targets in the CNS and their interactions with environmental toxicants
(Master thesis; Mastergradsoppgave, 2016-05-12)The exposure to pollutants is a serious and increasing health problem, which has been associated with increased morbidity and mortality among people. Many toxic compounds can accumulate in the environment and evidence suggests that most people have varying degrees of toxic compounds within their body. This can result in disruption of many physiological processes in the human body and the development ... -
Modelling of serotonergic receptors and molecular optimization of X-ray crystal structures of serotonin transporter and their interactions with exogenous compounds
(Master thesis; Mastergradsoppgave, 2016-05-12)The serotonin (5-hydroxytryptamine, 5-HT) receptors and transporter are in the serotonergic neurotransmission system, and believed to have a major role in pathology of depression. They are of pharmacological importance, being targeted by many nowadays antidepressants. It is therefore of great interest to understand their structural and functional properties for development of future drugs. There ... -
Modifier gene polymorphisms and influence on disease expression in FAP
(Master thesis; Mastergradsoppgave, 2009-05-20)Background: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant condition characterized by the appearance of hundreds to thousands of adenomatous polyps throughout the colon and rectum. If the condition is left untreated it will ultimately develop into colorectal cancer. Most of the articles available today concerning FAP focus on the adenomatous polyposis coli gene as this gene ... -
Modifier gene polymorphisms and influence on disease expression in HNPCC
(Master thesis; Mastergradsoppgave, 2009-05-20)Background Hereditary non-polyposis colorectal cancer(HNPCC) is an autosomal dominantly inherited predisposition to a variety of epithelial malignancies most notable colorectal and endometrial cancer. Unlike other genetic predispositions to colorectal cancer HNPCC does not present with a premalignant phenotype, which as such makes it difficult to predict when or if an affected person will present ... -
Molecular modeling of 3D structure of the oxytocin receptor. Discovery of novel oxytocin receptor agonists via molecular docking studies.
(Master thesis; Mastergradsoppgave, 2015-05-15)Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ... -
Molecular modeling of the monoamine transporters and their interactions with psychostimulants and other substances
(Mastergradsoppgave; Master thesis, 2023-05-15)The monoamines (i.e., dopamine, serotonin, and norepinephrine) are vital to the ontogeny, function, and plasticity of the nervous system. These neurotransmitters affect each other and regulate, amongst others, motor function, cognitive state, motivation, and stress reactions. The neurotransmission is mainly terminated by reuptake in monoamine transporters (MATs), i.e., the dopamine-, serotonin-, and ... -
Molecular modelling of interactions between antipsychotic drugs and receptors mediating antipsychotic effects and important side effects
(Master thesis; Mastergradsoppgave, 2021-05-10)Dopamine and serotonin are two neurotransmitters that exert their actions through mediation of dopaminergic and serotonergic receptors respectively. The receptors in focus in the current study, are the dopamine D2 and serotonin 5-HT2A receptors. Common for both receptors is that they are class A G-protein-coupled receptors consisting of seven transmembrane helices embedded in the lipid membrane of ... -
Molecular Modelling of PDE3A Catalytic Domain
(Master thesis; Mastergradsoppgave, 2020-05-14)<p>Recent studies have highlighted the clinical benefits of regulating phosphodiesterase-3 enzymes. Inhibition of PDE3A has proven to aid in preventing and treating cardiovascularrelated disorders and platelet dysfunction. Hypothermia is a condition that can cause cardiac arrest. However, there are no suitable inotropic drugs that are effective for use under hypothermic conditions. Being able to ... -
Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17
(Master thesis; Mastergradsoppgave, 2018-05-25)The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ... -
Molekylmodelleringsstudium av G-protein koblet østrogenreseptor (GPER)
(Mastergradsoppgave; Master thesis, 2017-05-15)G-protein koblet østrogenreseptor (GPER) har vist å ha en fysiologisk rolle i det reproduktive systemet, nervesystemet, endokrine systemet, immunsystemet og karsystemet. Den har også patofysiologisk rolle i flere forskjellige sykdommer inkludert kreft. G-protein koblet østrogenreseptor har blitt identifisert i nesten alle systemer i kroppen. Dermed er det en stor interesse for å få kjennskap til ... -
Mucus-penetrating drug carriers for vaginal drug delivery
(Master thesis; Mastergradsoppgave, 2015-05-13)Vaginal drug administration is a challenging approach due to the body´s natural defense mechanisms and specificity in formulation design. However, where applicable, topical drug delivery is preferable to systemic therapy. Firstly, it allows averting hepatic first pass effect and degradation by GI enzymes. Secondly, non-invasive application provides closer and direct contact with the affected area ... -
Mukus-penetrerende legemiddelbærere: hvordan modifisering av overflaten påvirker terapeutisk effekt
(Master thesis; Mastergradsoppgave, 2014-05-20)Seksuelt overførbare infeksjoner og andre gynekologiske sykdommer vil man helst behandle lokalt. Hos kvinner er vaginal administrasjon fordelaktig for behandling av nettopp slike sykdommer. Det er flere utfordringer som må overvinnes når farmasøytiske formuleringer til vaginal administrasjon skal utvikles; vagina har en evne til å rense seg selv, det skjer hele tiden fysiologiske forandringer i ... -
Naturlegemidler og plantebaserte legemidler - endringer i omsetning og lovgivning i perioden 2003-2011
(Master thesis; Mastergradsoppgave, 2013-05-20)Alternativ medisin har vesentlig interesse utenfor skolemedisin. Preparater fra naturen er et populært eksempel på alternative behandlingsmetoder. Markedet for naturmedisin er stort. I perioden fra 2003 til 2011 har det skjedd en del endringer i lovgivningen omkring naturlegemidler som kan påvirke forbruket. En deskriptiv studie av omsetning av naturlegemidler i perioden 2003-2011 er basert på ...
