Autophagy is an essential cellular process that is important to maintain homeostasis by degrading proteins, lipids and organelles during critical times like cellular or environmental stress conditions. Autophagy plays a critical role in human pathologies, since defective autophagy can lead to diseases like cancer, neurodegenerative- and inflammatory diseases. Fez1 (Fasciculation and elongation protein ...

Introduction — The aim of Edinburgh Improved Anticipatory Care and Treatment (IMPACT) service is to reduce admissions and re-admissions to hospital for people with LTCs. The service consists of nurse case managers co-ordinating patients’ care, including reviewing medication. As a pilot project, an arrangement was made to refer such patients to a team of primary care pharmacists for clinical medication ...

Introduction There is little data on immuno-suppressant administration and prescribing to transplant patients. It was considered a high risk area because errors in prescribing and administration of immuno-suppressants can potentially have serious consequences like graft loss, side effects and even death. The reality was however that the lack of data meant that no one knew whether this was an area ...

BACKGROUND: Denosumab is a medication for postmenopausal osteoporosis delivered as a subcutaneous injection. Within the National Health Service (NHS) Lothian, Scotland, the treatment is currently administered in a hospital setting. Feedback from patients and staff indicate that the drug could most likely be delivered in a community setting, which is in accordance with Scottish Government policy ...

Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ...

Background: The main cause to chronic myeloid leukemia (CML) is a translocation between chromosome 9 and 22, resulting in the Philadelphia chromosome, containing a BCR-ABL fusion-gene that encodes a constitutively active tyrosine kinase. Imatinib, a selective inhibitor of the tyrosine kinase, is the first-line treatment for CML-patients. However, drug-resistance is an increasing problem, and the ...

Vaginal infections are common in women of all ages and proper treatment is essential. The vaginal route of administration can be considered as favourable for the local therapy of vaginal infections. There are several vaginal dosage forms currently available; however, all suffer from limitations such as leakage and limited residence time at the site of action resulting in reduced therapeutic effect. ...

S100A4 er et lite kalsiumbindende protein som tilhører S100-proteinfamilien. Proteinet er vist å ha en viktig rolle i metastaseprosessen, bl.a. ved å stimulere kreftcellenes motilitet og invasjonsevne. I de senere år har man blitt klar over at flere av de observerte biologiske effektene av S100A4 kan skyldes ekstracellulært protein. Ved transient transfeksjon med et reporterkonstrukt for ...

Studies have shown that homogeneity is higher in ordered mixtures compared to random mixtures. Based on this ordered mixtures should be particularly suitable for the preparation of mini-tablets. The overall aim of the study was to compare the homogeneity of ordered mixtures prepared using different particle size of carrier particles, and test their suitability for preparation of mini-tablets. The ...

Sammendrag: Det er mangel på validerte metoder innen feltet klinisk farmasi. Kvalitetssikring av legemiddelbruk er viktig, og denne masteroppgaven er en del av et doktorgradsprosjekt i klinisk farmasi hvor overordnet mål er definert som ’Development of a standardized clinical pharmacist service for patients with established CHD’. Utvikling og bruk av Medication Assessment Tool har vist seg nyttig ...