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norskBlar i tittel Mastergradsoppgaver i farmasi
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Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin and/or mecillinam
(Master thesis; Mastergradsoppgave, 2017-05-16)The escalating emergence of AMR is a growing public health concern, and a result of the use and misuse of antibiotics since its introduction. To prevent the development of resistance and preserve the efficacy of antimicrobial agents, new treatment strategies is of utmost importance. One possible approach may be to take advantage of collateral sensitivity, a phenomenon where bacteria acquiring ... -
Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin and/or mecillinam
(Master thesis; Mastergradsoppgave, 2017-05-16)The escalating emergence of AMR is a growing public health concern, and a result of the use and misuse of antibiotics since its introduction. To prevent the development of resistance and preserve the efficacy of antimicrobial agents, new treatment strategies is of utmost importance. One possible approach may be to take advantage of collateral sensitivity, a phenomenon where bacteria acquiring ... -
Collateral sensitivity in clinical mecillinam resistant isolates of Escherichia coli
(Master thesis; Mastergradsoppgave, 2016-05-13)Background The rapid increase in antimicrobial resistance (AMR) has become a major threat to the successful management of infectious diseases. To counteract this global threat, development of novel treatment strategies is essential. A promising strategy may be exploiting collateral sensitivity; a phenomenon that occurs when a microorganism that has developed resistance to one antimicrobial agent, ... -
Computational studies on the human GnRH-I and the GnRH-receptor
(Mastergradsoppgave; Master thesis, 2022-05-12)Gonadotropin-releasing hormone receptor (GnRH-R), which is a Class A G-protein coupled receptor (GPCR), has a vital role in the regulation of sex hormones. The receptor also has a prominent role in diseases, with examples being reproductive cancers and non-reproductive cancers like glioblastoma. Gonadotropin-releasing hormone (GnRH) agonists have been proven to combat cell proliferation in cancers. ... -
Continuity of care during hospital stay: A review and evaluation of medicines reconciliation on admission
(Master thesis; Mastergradsoppgave, 2009-05)Background: Errors in the stage of prescribing make approximately 16 % of all medication errors. There is a need to identify the frequency of this, and also to assess the impact of contributions by pharmacists to the patient’s care. Aim and objectives: To characterise the nature and frequency of medicines errors in patients during the process of admission to hospital, and also to evaluate ... -
Design and synthesis of novel cyclopentapeptide antagonist for the chemokine receptor CXCR4
(Master thesis; Mastergradsoppgave, 2008-06-16)CXCR4 is a GPCR that by activation of its ligand CXCL12 is involved in the pathology of several diseases, examples being cancer and rheumatoid arthritis. It has also shown to play a crucial role for HIV-1 entry into T-cells and the development of AIDS. Several cyclopentapeptides (CPPs) based on the sequence D-Tyr-Arg-Arg-2-Nal-Gly of the lead compound FC131 have shown to have antagonistic activity. ... -
Design og syntese av cyklopentapeptidbaserte CXCR4 antagonister: Variasjon av essensiell aromatisk substituent
(Mastergradsoppgave; Master thesis, 2009-05-20)SAMMENDRAG CXCR4 er en kjemokinreseptor som er involvert i en rekke biologiske prosesser i kroppen, blant annet angiogenese, neurogenese og dannelse av blodceller i embryostadiet. I voksne er CXCR4 funnet å være involvert i sykdommer som HIV, reumatoid artritt og kreft. I litteraturen finnes det potente CXCR4 antagonister (AMD3100, KRH1636, FC131) som har vist effekt mot HIV-1, reumatoid artritt ... -
Design, synthesis and structural studies of relaxin receptor modulators
(Master thesis; Mastergradsoppgave, 2011-06)The relaxin family of peptides consists of seven structurally related peptides, with a wide variety of biological functions, ranging from involvement in reproductive processes to functions as neuroendocrine modulators. Because of the complex, two-chained structure of the relaxins, and their lack of specificity for the various relaxin family receptors (RXFPs), design of simpler, more selective ... -
Det metastaseassosierte proteinet S100A4 i orale plateepitelkarsinomcellelinjer - kartlegging av effekter på proteolytiske enzymer viktige for invasjon og metastase
(Master thesis; Mastergradsoppgave, 2012-05-20)Oralkreft er en kreftform forbundet med dårlig prognose, som hovedsakelig skyldes hyppig forekomst av lokal invasjon og metastase til lymfeknuter. Behandlingen består i dag hovedsakelig av kirurgi og stråling, men på tross av stadig nye og bedre behandlingsformer er mortaliteten for pasienter med oralkreft uendret de siste 30 årene. Med den vedvarende høye dødsraten av oralkreft er det et tydelig ... -
Determination of Cysteine Connectivity in Bioactive Peptides
(Master thesis; Mastergradsoppgave, 2014-05-20)Conotoxins are diverse and well-studied, and is therefore suited as a model to develop a general method for analyzing disulfide-rich peptides. To investigate the folding of both commercially available and self-synthesized Conotoxins, an UHPLC-MS/MS method was developed where one disulfide-bridge was reduced at the time and alkylated with different maleimides. The results from the UHPLC-MS/MS method ... -
Developement of mucoadhesive polymer-coated liposomes for hydration of the oral mucosa
(Master thesis; Mastergradsoppgave, 2013-05-18)Dry mucus in the oral cavity is uncomfortable for patients and can lead to other additional illnesses. Reduced or absence of saliva secretion, caused by the diseases, side effects of drugs, aging, or radiotherapy, can result in issues related to xerostomia and dental health. A system that could contribute to increased hydration of the mucus would reduce the discomfort for the patient. In addition, ... -
Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates
(Master thesis; Mastergradsoppgave, 2017-05-15)Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ... -
The Development of a pharmaceutical care plan in the Scottish mental health service
(Master thesis; Mastergradsoppgave, 2008-06)Abstract Background Pharmaceutical care planning is increasingly seen as the most effective manner by which to deliver pharmaceutical care services to the patient. The role of the pharmacist, both specialist and generalist, is paramount, as much of the treatment in Mental Health is dependent on the effective management of the patients medication(1). Consequently, there is a need for standardised ... -
Development of an analytical method for detection and quantification of cannabis and cannabinoid analogues in urine
(Master thesis; Mastergradsoppgave, 2010-05-20)Cannabis is a drug mainly consumed for its euphoric effects; users may become happy, careless and relaxed. The direct effects of cannabis in sports are performance decreasing, but cannabis can be used as a doping agent due to its relaxing properties. For these reasons, cannabinoids are prohibited in sports during competition by the World Anti-Doping Agency (WADA). In the context of the fight ... -
Development of an in vitro model to study compromised skin: pigskin versus the Phospholipid Vesicle-based Permeation Assay
(Master thesis; Mastergradsoppgave, 2013-05-20)When the skin barrier is reduced, penetration of topical and transdermal drugs could potentially be enhanced and the risk of systemic effects is increased. The studies analysing penetration through intact or diseased skin are often limited by the variability in obtaining specimens of representative skin. The phospholipid vesicle-based permeation assay is an artificial barrier mimicking human stratum ... -
Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases
(Master thesis; Mastergradsoppgave, 2012-06)Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ... -
Development of chitosan-coated liposomes for improved therapy of vaginal infections: clotrimazole as model drug
(Master thesis; Mastergradsoppgave, 2012-05)For many drugs the vaginal route of administration is favorable, particularly for local therapy of specific gynecological diseases such as vaginal infections. A large variety of pharmaceutical preparations have been developed for vaginal delivery, nevertheless, the efficiency of currently available dosage forms is often limited by their poor retention time at the vaginal site. Physiological changes ... -
Development of COFRADIC HPLC system for proteomics. Sorting of N-terminal peptides
(Master thesis; Mastergradsoppgave, 2014-05-20)Proteomics, the study of the proteins constituting the proteome, has featured in the past few years as an essential tool in a number of diverse areas of therapeutic research for detection of the initial stage of a disease, for consideration of therapy response and for disintegrating fundamental pathophysiological mechanisms. Proteomics has a wide range of applications such as diabetes research, ... -
Development of DNA Nanoparticles with Properties for Enhanced Biofilm Uptake
(Mastergradsoppgave; Master thesis, 2022-05-11)Microbial biofilms account for up to 80% of all bacterial infections. They are described as small structural communities of bacteria which are embedded in a self-produced extracellular (EPS) matrix. This EPS matrix poses a substantial challenge for antimicrobial treatment by hindering traversal of antimicrobial agents. Nanotechnology based drug delivery systems (DDS) offer a promising solution ... -
The development of electrospun chloramphenicol containing wound dressing
(Master thesis; Mastergradsoppgave, 2021-05-11)Wound healing is among the most complex processes in the human body that is greatly coordinated with a focus to rebuild tissue integrity and restore the skin´s protective barrier. The normal healing process is disrupted in chronic wounds, leading to delayed wound healing due to several underlying factors such as aging, obesity, and diabetes. Among chronic wounds 50 % are infected and up to 78 % of ...
