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dc.contributor.authorStepien, Magdalena
dc.contributor.authorJenab, Mazda
dc.contributor.authorFreisling, Heinz
dc.contributor.authorBecker, Niels-Peter
dc.contributor.authorCzuban, Magdalena
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorMancini, Francesca Romana
dc.contributor.authorSavoye, Isabelle
dc.contributor.authorKatzke, Verena
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorIqbal, Khalid
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBamia, Christina
dc.contributor.authorOrfanos, Philippos
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorTumino, Rosario
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorMerino, Susana
dc.contributor.authorJakszyn, Paula
dc.contributor.authorSánchez, María-José
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorHuerta, José María
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorBoden, Stina
dc.contributor.authorvan Guelpen, Behany
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorBradbury, Kathryn E.
dc.contributor.authorCross, Amanda J.
dc.contributor.authorSchomburg, Lutz
dc.contributor.authorHughes, David J.
dc.date.accessioned2020-09-05T10:35:29Z
dc.date.available2020-09-05T10:35:29Z
dc.date.issued2017-07-01
dc.description.abstractAdequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.en_US
dc.description.sponsorshipHealth Research Board of Ireland The European Commission The International Agency for Research on Canceren_US
dc.identifier.citationStepien M, Jenab M, Freisling H, Becker N, Czuban M, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault M, Mancini FR, Savoye I, Katzke V, Kühn T, Boeing H, Iqbal K, Trichopoulou A, Bamia C, Orfanos P, Palli D, Sieri S, Tumino R, Naccarati A, Panico S, Bueno-De-Mesquita HB, Peeters PH, Weiderpass E, Merino S, Jakszyn P, Sánchez M, Dorronsoro M, Huerta JM, Barricarte A, Boden S, van Guelpen, Wareham N, Khaw K, Bradbury KE, Cross AJ, Schomburg L, Hughes DJ. Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Carcinogenesis. 2017;38(7):699-707en_US
dc.identifier.cristinIDFRIDAID 1514046
dc.identifier.doi10.1093/carcin/bgx051
dc.identifier.issn0143-3334
dc.identifier.issn1460-2180
dc.identifier.urihttps://hdl.handle.net/10037/19224
dc.language.isoengen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.journalCarcinogenesis
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2017 Oxford University Pressen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectcolorectal canceren_US
dc.subjectbiological markersen_US
dc.subjectfollow-upen_US
dc.subjectcopperen_US
dc.subjectcopper measurementen_US
dc.subjectdiagnosisen_US
dc.subjectzincen_US
dc.subjectnutrition in canceren_US
dc.titlePre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohorten_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US
dc.typePreprinten_US
dc.typeManuskripten_US


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