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dc.contributor.authorYang, Zhongjun
dc.contributor.authorCui, Qingyu
dc.contributor.authorAn, Ran
dc.contributor.authorWang, Juan
dc.contributor.authorSong, Xiaobo
dc.contributor.authorShen, Yu
dc.contributor.authorWang, Mingyu
dc.contributor.authorXu, Hai
dc.date.accessioned2020-11-02T08:17:58Z
dc.date.available2020-11-02T08:17:58Z
dc.date.issued2020-04-29
dc.description.abstract<i>Background</i> - Recurrent aphthous stomatitis (RAS) is the most common form of oral ulcerative disease, whose cause is still unknown. Researchers have found the association of many factors with the occurrence of RAS, and proposed oral bacterial infection could be a cause for this disease.<p> <p><i>Methods</i> - To investigate whether the occurrence of RAS is associated with oral bacterial infection, we performed high throughput sequencing analysis of bacterial samples collected from the normal oral mucosa and aphthous ulcers of 24 patients.<p> <p><i>Results</i> - Firmicutes, Proteobacteria and Bacteriodetes were the most abundant phyla in the microbiomes analysed. The alpha diversities of the oral mucosa and aphthous ulcer microbiomes were similar, suggesting a similar richness and diversity. The NMDS analysis showed the oral mucosa and aphthous ulcer microbiomes are significantly different. This suggestion is further supported by Anosim, MRPP, and Adonis analyses. More detailed comparison of the two groups of microbiomes suggested that the occurrence of RAS is significantly associated with the increase of <i>Escherichia coli</i> and <i>Alloprevotella</i>, as well as the decrease of <i>Streptococcus</i>.<p> <p><i>Conclusions</i> - Considering E. coli is a very common intestinal bacterium, we propose that <i>E. coli</i> colonization could be a cause for RAS, and controlling E. coli colonization could help curing RAS.en_US
dc.identifier.citationYang Z, Cui, An, Wang J, Song XS, Shen Y, Wang M, Xu H. Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis(RAS)-affected patients. BMC Oral Health. 2020;20en_US
dc.identifier.cristinIDFRIDAID 1843825
dc.identifier.doi10.1186/s12903-020-01115-5
dc.identifier.issn1472-6831
dc.identifier.urihttps://hdl.handle.net/10037/19732
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Oral Health
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleComparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis(RAS)-affected patientsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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