dc.contributor.author | Yang, Zhongjun | |
dc.contributor.author | Cui, Qingyu | |
dc.contributor.author | An, Ran | |
dc.contributor.author | Wang, Juan | |
dc.contributor.author | Song, Xiaobo | |
dc.contributor.author | Shen, Yu | |
dc.contributor.author | Wang, Mingyu | |
dc.contributor.author | Xu, Hai | |
dc.date.accessioned | 2020-11-02T08:17:58Z | |
dc.date.available | 2020-11-02T08:17:58Z | |
dc.date.issued | 2020-04-29 | |
dc.description.abstract | <i>Background</i> - Recurrent aphthous stomatitis (RAS) is the most common form of oral ulcerative disease, whose cause is still unknown. Researchers have found the association of many factors with the occurrence of RAS, and proposed oral bacterial infection could be a cause for this disease.<p>
<p><i>Methods</i> - To investigate whether the occurrence of RAS is associated with oral bacterial infection, we performed high throughput sequencing analysis of bacterial samples collected from the normal oral mucosa and aphthous ulcers of 24 patients.<p>
<p><i>Results</i> - Firmicutes, Proteobacteria and Bacteriodetes were the most abundant phyla in the microbiomes analysed. The alpha diversities of the oral mucosa and aphthous ulcer microbiomes were similar, suggesting a similar richness and diversity. The NMDS analysis showed the oral mucosa and aphthous ulcer microbiomes are significantly different. This suggestion is further supported by Anosim, MRPP, and Adonis analyses. More detailed comparison of the two groups of microbiomes suggested that the occurrence of RAS is significantly associated with the increase of <i>Escherichia coli</i> and <i>Alloprevotella</i>, as well as the decrease of <i>Streptococcus</i>.<p>
<p><i>Conclusions</i> - Considering E. coli is a very common intestinal bacterium, we propose that <i>E. coli</i> colonization could be a cause for RAS, and controlling E. coli colonization could help curing RAS. | en_US |
dc.identifier.citation | Yang Z, Cui, An, Wang J, Song XS, Shen Y, Wang M, Xu H. Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis(RAS)-affected patients. BMC Oral Health. 2020;20 | en_US |
dc.identifier.cristinID | FRIDAID 1843825 | |
dc.identifier.doi | 10.1186/s12903-020-01115-5 | |
dc.identifier.issn | 1472-6831 | |
dc.identifier.uri | https://hdl.handle.net/10037/19732 | |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.relation.journal | BMC Oral Health | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2020 The Author(s) | en_US |
dc.subject | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710 | en_US |
dc.title | Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis(RAS)-affected patients | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |