• Real-time polymerase chain reaction species specific for Neisseria Gonorrhoeae 

      Olsen, Merethe Elise (Master thesis; Mastergradsoppgave, 2008-05)
      Gonorrhea is a sexually transmitted disease caused by bacteria called gonococci. The disease was described in ancient times, but until the late nineteenth century it was mixed up with syphilis. Eventually microscopy could differ between the organisms and give a reliable diagnosis. Human is the only known reservoir for gonorrhea. It is transferred during all acts of sexual activity, and an infection ...
    • The role of MMP-2 and MMP-14 in cell migration and invasion 

      Okoli, Ndidiamaka Chinelo (Master thesis; Mastergradsoppgave, 2014-02-03)
      Cancer is becoming a global epidemic in recent times and can affect different organs in the body and even more worrying is that they do not have a common cause. Several factors have been implicated in the onset and spread of cancers, one of which are the metalloproteinases (MMPs). The MMPs utilize the same strategy they employ in normal physiological processes in pathology, thus creating a dilemma ...
    • Role of the mannose receptor in tumor associated macrophages. Studies in a mouse melanoma model 

      Rønningen, Iselin (Master thesis; Mastergradsoppgave, 2014-04-15)
      Tumor-associated macrophages (TAMs) play an important role in cancer-related inflammation. TAMs develop M2 polarization which may support tumor growth. Mannose receptor (MR) expression is a hallmark for this cell-subpopulation, and the MR has recently been suggested to be involved in TAM polarization. The aim of the study was to investigate the role of MR in TAM polarization and tumor development ...
    • Study of interaction between BK virus large T-antigen and agnoprotein 

      Adou, Koman Mireille Sophie Chinan (Master thesis; Mastergradsoppgave, 2011-08)
      Human polyomavirus BK (BKV) is a non enveloped virus with a double-stranded, circular DNA genome. BKV infects >70% of the human population world-wide. Infection occurs predominantly during childhood and the virus remains in a latent state throughout life in the immune competent individuals. In the context of immunosuppression, however, reactivation occurs and can lead to renal stenosis and interstitial ...
    • A study of possible genetic causes of inherited breast and ovarian cancer in a Norwegian cancer population 

      Jarhelle, Elisabeth (Master thesis; Mastergradsoppgave, 2013-05-15)
      Homologous recombination repair (HRR) is an important repair mechanism, and mutations disrupting the function of this machinery might contribute to cancer formation. Several proteins interact in this mechanism, and the two best known are BRCA1 and BRCA2. Mutations in their corresponding genes BRCA1 and BRCA2 are found in 40% of hereditary breast and ovarian cancer cases. However, there are still ...
    • A study of the interaction between MAPKAP Kinase 5 / MK5 and DNAJB1 

      Lægreid, Kari Jenssen (Master thesis; Mastergradsoppgave, 2011-05-02)
      The mitogen activated protein kinases (MAPK) are a large and diverse family of protein kinases, contributing to the cells ability to respond to external stimuli by relaying messages in a well orchestrated way until they reach their final destinations. This is achieved through successive phosphorylation events. One member of this large family is mitogen activated protein kinase activated protein ...
    • A study of the protein kinase MK5's effect on melanoma cell proliferation 

      Dumitriu, Gianina Aurica (Master thesis; Mastergradsoppgave, 2012-09-14)
      The mitogen-activated protein kinases (MAPKs) play a crucial role in cellular processes such as proliferation, differentiation, apoptosis, metabolism and motility. Both conventional and atypical MAPKs can phosphorylate other proteins referred to as MAPK- activated protein kinases (MAPKAPK) such as MK5 or p38-regulated /activated protein kinase. Mutations in the MK5 gene have been detected in lung, ...
    • Theoretical and experimental studies of thermolysin inhibition 

      Wuxiuer, Yimingjiang (Master thesis; Mastergradsoppgave, 2008-05-15)
      Zinc-metalloproteinases play a key role in the biosythesis and metabolism of different bioactive peptides. As a member of zinc-metalloproteinases, thermolysin has served as a model system to study the inhibition mechanism of other metalloproteinases. Inhibitors of thermolysin have considerable potential as therapeutic agents. In the present master thesis, docking calculations were performed and ...
    • The world of β-glucans : a review of biological roles, applications and potential areas of research 

      Ali, Syed Haris (Master thesis; Mastergradsoppgave, 2009-05-15)
      Among many known and tested immunomodulators, polysaccharides isolated from various natural sources occupy a prominent position. An important group of these polysaccharides is represented by the homopolymers of β-glucose, called β-glucans. Their very low-to-negligible toxicity and immunomodulating effects show the promise it has in the therapy of a variety of infectious and cancer illnesses. ...