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norskBrowsing Mastergradsoppgaver i biologi (Helsefak) by Issue Date
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Downstream gene expression of wild type p53 tumor suppressor gene versus mutated and null p53
(Master thesis; Mastergradsoppgave, 2006-11)P53 is a key tumor suppressor and transcription factor protecting us from cancer. The wild type p53 protein functions as a regulatory protein, triggering a variety of cellular responses to different signals. Activation of ... -
The 5-HT1E receptor. Receptor structure and ligand interactions.
(Master thesis; Mastergradsoppgave, 2006-12-08)5-HT (5-Hydroxytryptamine; Serotonin) is the neurotransmitter with the highest number of known receptors in humans, and the importance of 5-HT is also reflected in the number of species using 5-HT as a signalling molecule ... -
Real-time polymerase chain reaction species specific for Neisseria Gonorrhoeae
(Master thesis; Mastergradsoppgave, 2008-05)Gonorrhea is a sexually transmitted disease caused by bacteria called gonococci. The disease was described in ancient times, but until the late nineteenth century it was mixed up with syphilis. Eventually microscopy could ... -
Theoretical and experimental studies of thermolysin inhibition
(Master thesis; Mastergradsoppgave, 2008-05-15)Zinc-metalloproteinases play a key role in the biosythesis and metabolism of different bioactive peptides. As a member of zinc-metalloproteinases, thermolysin has served as a model system to study the inhibition mechanism ... -
Et eksperimentelt studium av kreftceller fra livmorhals - Strålesensitivitet, effektutvikling og cGMP nivåer
(Master thesis; Mastergradsoppgave, 2008-06)I denne oppgaven ble kreftceller fra livmorhals bestrålt med gammastråler. Strålingens effekt på celletetthet, celledød og cellesyklus ble undersøkt for å si noe om disse cellenes strålesensitivitet. Den ekstracellulære ... -
Prevalence of plasmid-mediated quinolone resistance in Norwegian and Swedish clinical isolates of Escherchia coli and Klebsiella spp.
(Master thesis; Mastergradsoppgave, 2008-06-12)The aim of this study was to examine the presence of plasmid-mediated qnr and aac(6')-Ib-cr resistance genes among Escherichia coli and Klebsiella spp. clinical isolates obtained between 2003 and 2005 from Norway and Sweden ... -
A molecular study of putative pili structures in Enterococuus faecium
(Master thesis; Mastergradsoppgave, 2008-12)Infections caused by Enterococcus faecium have increased over the last few decades. In this thesis there has been an attempt to identify putative pili proteins in E. faecium. The putative genes were ligated into a pENTR ... -
Human articular chondrocytes express Chemerin receptor, ChemR23, which conveys inflammatory signalling
(Master thesis; Mastergradsoppgave, 2008-12-17)Common features of arthritis include destruction of extracellular matrices in cartilage and bone as a result of chronic inflammation. Cartilage deterioration is generally described as a result from the effect of immune ... -
The world of β-glucans : a review of biological roles, applications and potential areas of research
(Master thesis; Mastergradsoppgave, 2009-05-15)Among many known and tested immunomodulators, polysaccharides isolated from various natural sources occupy a prominent position. An important group of these polysaccharides is represented by the homopolymers of β-glucose, ... -
Characterization of the Arabidopsis thaliana homologue of NBR1
(Master thesis; Mastergradsoppgave, 2009-05-15)It is now well established that p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates. Research on autophagy in plants is ... -
Molecular and biochemical characterisation of naturally occurring hyperexpressed and mutated extended spectrum AmpC beta-lactamases in Norwegian clinical isolates of Escherichia coli
(Master thesis; Mastergradsoppgave, 2009-11-17)Jeg har karakterisert kliniske E. coli isolater, med nedsatt følsomhet for cefalosporiner, på nukleotid og amino syre nivå. -
The biological cost of genetic elements.
(Master thesis; Mastergradsoppgave, 2010-03-15)The emergence and increase of antimicrobial resistance among bacterial populations has raised interest in the factor that contributes to this situation. Mobile genetic elements and in particular integrons have been found ... -
King crab proteases: as stimulators of an inflammatory pathway in human airway epithelial cells
(Master thesis; Mastergradsoppgave, 2010-03-22)In these studies, we focus on moricrase (enzyme mixture from hapatopancreas of king crab) as an activator of inflammatory responses in airway cells. Taking under consideration that serine proteases, such as trypsin, are ... -
The antioxidant system of arctic seabirds and the effect of HOCs on antioxidant capacity of kidney tissue
(Master thesis; Mastergradsoppgave, 2010-06-15)The arctic is exposed to a wide range of pollutants which originate from industrialized areas located in temperate regions. Halogenated organic contaminants (HOCs) are of special concern due to their persistency and ability ... -
Development of new tissue culture protocols for enrichment of CD4 T cells associated with neonatal alloimmune thrombocytopenia
(Master thesis; Mastergradsoppgave, 2010-11-15)Neonatal alloimmune thrombocytopenia (NAIT) is most commonly caused by destruction of foetal platelets by maternal antibodies reactive to human platelet antigen (HPA)-1a. The activation of antigen-primed B cells to ... -
Aminoglycoside resistance in clinical Gram-negative isolates from Norway
(Master thesis; Mastergradsoppgave, 2011-04-06)Aminoglycosides represent an important class of antimicrobial agents. The prevalence of aminoglycoside resistance among Gram-negative bacteria in Norway is low, but an increased prevalence among clinical isolates of ... -
A study of the interaction between MAPKAP Kinase 5 / MK5 and DNAJB1
(Master thesis; Mastergradsoppgave, 2011-05-02)The mitogen activated protein kinases (MAPK) are a large and diverse family of protein kinases, contributing to the cells ability to respond to external stimuli by relaying messages in a well orchestrated way until they ... -
Directed evolution of Escherichia coli LacZ gene to create diversity in glycosidic bonds hydrolysis
(Master thesis; Mastergradsoppgave, 2011-05-16)Starting with LacZ of Escherichia coli, coding for β-galactosidase, the aim of the thesis project is to apply in vitro directed evolution techniques to help create other glycosidic bond hydrolysis activities. This was done ... -
Partial characterization of predicted ABCC5 inhibitors by the aid of human erythrocyte inside-out vesicles
(Master thesis; Mastergradsoppgave, 2011-06-24)ABCC5 is a member of the superfamily of ABC-transporters, and it has been identified as an efflux transporter of cGMP. This transporter is also involved in export of antibiotic and cytostatic drugs from target cells, and ... -
Study of interaction between BK virus large T-antigen and agnoprotein
(Master thesis; Mastergradsoppgave, 2011-08)Human polyomavirus BK (BKV) is a non enveloped virus with a double-stranded, circular DNA genome. BKV infects >70% of the human population world-wide. Infection occurs predominantly during childhood and the virus remains ...