Revisiting the radiographic assessment of osteoporosis-Osteopenia in children 0-2 years of age. A systematic review
Permanent link
https://hdl.handle.net/10037/20040Date
2020-11-02Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Rosendahl, Karen; Lundestad, Anette; Bjørlykke, John Asle; Lein, Regina Küfner; Angenete, Oskar W; Augdal, Thomas Angell; Müller, Lil-Sofie Ording; Jaramillo, DiegoAbstract
Methods - We undertook systematic searches in Medline, Embase and Svemed+, covering 1946–2020. Unpublished material was searched in Clinical trials and International Clinical Trials Registry Platform (ICTRP). Both relevant subject headings and free text words were used for the following concepts: osteoporosis or osteopenia, radiography, children up to 6 years.
Results - A total 5592 publications were identified, of which none met the inclusion criteria for the primary outcome; the degree of bone loss warranted before osteopenia becomes visible radiographically. As for the secondary outcome, 21 studies were identified. None of the studies was true population based and none covered the pre-defined age range from 0–2 years. However, four studies of which three having a crossectional and one a longitudinal design, included newborns while one study included children 0–2 years.
Conclusions - Despite an extensive literature search, we did not find any studies supporting the assumption that a 20–40% bone loss is required before osteopenia becomes visible on radiographs. Reference values for cortical thickness were sparse. Further studies addressing this important topic are warranted.