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dc.contributor.authorFenton, Christopher Graham
dc.contributor.authorTaman, Hagar
dc.contributor.authorFlorholmen, Jon
dc.contributor.authorSørbye, Sveinung
dc.contributor.authorPaulssen, Ruth H
dc.date.accessioned2020-12-21T14:05:21Z
dc.date.available2020-12-21T14:05:21Z
dc.date.issued2020-04-23
dc.description.abstract<i>Background</i> - This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was investigated by applying the next-generation technology RNA-Seq.<p> <p><i>Methods</i> - Mucosal biopsies from patients in remission (n = 14), patients with active UC (n = 14), and healthy control patientss (n = 16) underwent whole-transcriptome RNA-Seq. Principal component analysis, cell deconvolution methods, gene profile enrichment, and pathway enrichment methods were applied to define a specific transcriptional signature of UC in remission.<p> <p><i>Results</i> - Analyses revealed specific transcriptional signatures for UC in remission with increased expression of genes involved in O-glycosylation (<i>MUC17</i>, <i>MUC3A</i>, <i>MUC5AC</i>, <i>MUC12</i>, <i>SPON1</i>, <i>B3GNT3</i>), ephrin-mediated repulsion of cells (<i>EFNB2E</i>, <i>EFNA3</i>, <i>EPHA10</i>, <i>EPHA1</i>), GAP junction trafficking (<i>TUBA1C</i>, <i>TUBA4A</i>, <i>TUBB4B</i>, <i>GJB3</i>, <i>CLTB</i>), and decreased expression of several toll-like receptors (<i>TLR1</i>, <i>TLR3</i>, <i>TLR5</i>, <i<TLR6</i>).<p> <p><i>Conclusions</i> - This study reveals specific transcriptional signatures for remission. Partial restoration and improvement of homeostasis in the epithelial mucus layer and revival of immunological functions were observed. A clear role for bacterial gut flora composition can be implied. The results can be useful for the development of treatment strategies for UC in remission and may be useful targets for further investigations aiming to predict the outcome of UC in the future.en_US
dc.identifier.citationFenton CG, Taman HM, Florholmen J, Sørbye SW, Paulssen RH. Transcriptional signatures that define ulcerative colitis in remission. Inflammatory Bowel Diseases. 2020:1-12en_US
dc.identifier.cristinIDFRIDAID 1861187
dc.identifier.doi10.1093/ibd/izaa075
dc.identifier.issn1078-0998
dc.identifier.issn1536-4844
dc.identifier.urihttps://hdl.handle.net/10037/20116
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalInflammatory Bowel Diseases
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleTranscriptional signatures that define ulcerative colitis in remissionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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