Show simple item record

dc.contributor.authorWilsgaard, Tom
dc.contributor.authorVangen-Lønne, Anne Merete
dc.contributor.authorMathiesen, Ellisiv B
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorNjølstad, Inger
dc.contributor.authorHeiss, Gerardo
dc.contributor.authorDanaei, Goodarz
dc.date.accessioned2021-01-07T11:23:38Z
dc.date.available2021-01-07T11:23:38Z
dc.date.issued2020-05-24
dc.description.abstract<i>Objectives</i> - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. <p> <p><i>Design and setting</i> - A populations-based cohort study with repeated measurements, the Tromsø Study. <p> <p><i>Primary outcome measure</i> - Myocardial infarction. <p> <p><i>Participants</i> - We estimated the relative and absolute risk reduction under feasible and intensive risk reduction strategies for smoking, physical activity, alcohol drinking, body mass index, total serum cholesterol and systolic blood pressure in 14 965 men and women with 19 years of follow-up (1994–2013). <p> <p><i>Results</i> - The estimated 19-year risk of MI under no intervention was 7.5% in individuals with baseline mean age 49.3 years (range 25–69). This risk was reduced by 30% (95% CI 19% to 39%) under joint feasible interventions on all risk factors, and 70% (60%, 78%) under a set of more intensive interventions. The most effective interventions were lowering of total cholesterol to 5.18 mmol/L and lowering of systolic blood pressure to 120 mm Hg (33% and 37% lower MI risk, respectively). The absolute risk reductions were significantly larger in men, in older participants, in smokers and in those with low education. <p> <p><i>Conclusion</i> - Modification of population levels of cardiovascular risk factors could have prevented close to one-third of the cases of MI in the municipality of Tromsø during 19 years of follow-up.en_US
dc.identifier.citationWilsgaard, Vangen-Lønne, Mathiesen, Løchen, Njølstad, Heiss, Danaei. Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study. BMJ Open. 2020
dc.identifier.cristinIDFRIDAID 1854998
dc.identifier.doi10.1136/bmjopen-2019-035584
dc.identifier.issn2044-6055
dc.identifier.urihttps://hdl.handle.net/10037/20184
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalBMJ Open
dc.relation.projectIDNorges forskningsråd: 289440
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleHypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record