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dc.contributor.authorDietrichs, Erik Sveberg
dc.contributor.authorSelli, Anders Lund
dc.contributor.authorKondratiev, Timofei
dc.contributor.authorMcGlynn, Karen
dc.contributor.authorSmith, Godfrey L
dc.contributor.authorTveita, Torkjel
dc.date.accessioned2021-01-15T09:21:31Z
dc.date.available2021-01-15T09:21:31Z
dc.date.issued2021-01-04
dc.description.abstractAccidental hypothermia is associated with increased risk for arrhythmias. QRS/QTc is proposed as an ECG-marker, where decreasing values predict hypothermia-induced ventricular arrhythmias. If reliable it should also predict nonappearance of arrhythmias, observed in species like rat that regularly tolerate prolonged hypothermia.<p> <p>A rat model designed for studying cardiovascular function during cooling, hypothermia and subsequent rewarming was chosen due to species-dependent resistance to ventricular arrhythmias. ECG was recorded throughout the protocol.<p> <p>No ventricular arrhythmias occurred during experiments. QRS/QTc increased throughout the cooling period and remained above normothermic baseline until rewarmed.<p> <p>Different from the high incidence of hypothermia-induced ventricular arrhythmias in accidental hypothermia patients, where QRS/QTc ratio is decreased in moderate hypothermia; hypothermia and rewarming of rats is not associated with increased risk for ventricular fibrillation. This resistance to lethal hypothermia-induced arrhythmias was predicted by QRS/QTc.en_US
dc.identifier.citationDietrichs ES, Selli AL, Kondratiev T, McGlynn K, Smith GL, Tveita T. Resistance to ventricular fibrillation predicted by the QRS/QTc - ratio in an intact rat model of hypothermia/rewarming. Cryobiology. 2021en_US
dc.identifier.cristinIDFRIDAID 1865012
dc.identifier.issn0011-2240
dc.identifier.issn1090-2392
dc.identifier.urihttps://hdl.handle.net/10037/20290
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalCryobiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleResistance to ventricular fibrillation predicted by the QRS/QTc - ratio in an intact rat model of hypothermia/rewarmingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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