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dc.contributor.authorClarelli, Fabrizio
dc.contributor.authorLiang, Jingyi
dc.contributor.authorMartinecz, Antal
dc.contributor.authorHeiland, Ines
dc.contributor.authorWiesch, Pia Abel Zur
dc.date.accessioned2021-01-15T14:50:21Z
dc.date.available2021-01-15T14:50:21Z
dc.date.issued2019-11-25
dc.description.abstractOptimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are also used to translate drug action from in vitro to in vivo conditions or from animal models to human patients. Recently, mathematical models that incorporate drug-target binding and subsequent downstream responses have been shown to advance our understanding and increase predictive power of drug efficacy predictions. We here discuss current approaches of modeling drug binding kinetics that aim at improving model-based drug development in the future. This in turn might aid in reducing the large number of failed clinical trials.en_US
dc.identifier.citationClarelli F, Liang J, Martinecz A, Heiland I, Wiesch PAZ. Multi-scale modeling of drug binding kinetics to predict drug efficacy. Cellular and Molecular Life Sciences (CMLS). 2020;77(3):381-394en_US
dc.identifier.cristinIDFRIDAID 1868873
dc.identifier.issn1420-682X
dc.identifier.issn1420-9071
dc.identifier.urihttps://hdl.handle.net/10037/20304
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalCellular and Molecular Life Sciences (CMLS)
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/262686/Norway/Predicting optimal antibiotic treatment regimens//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/?/73307?/?/?/?/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/?/75468?/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.titleMulti-scale modeling of drug binding kinetics to predict drug efficacyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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