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Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro

Permanent link
https://hdl.handle.net/10037/22034
DOI
https://doi.org/10.1016/j.carbpol.2021.117939
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Date
2021-03-16
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Hemmingsen, Lisa Myrseth; Giordani, Barbara; Pettersen, Ann Kristin; Vitali, Beatrice; Basnet, Purusotam; Skalko-Basnet, Natasa
Abstract
Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine (CHX; ∼50 μg/mg lipid) as a model MAA were incorporated into chitosan hydrogel. The novel CHX-liposomes-in-hydrogel formulation was optimized for skin therapy. It significantly inhibited the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophage and almost completely reduced biofilm formation. Moreover, it reduced Staphylococcus aureus and Pseudomonas aeruginosa adherent bacterial cells in biofilm by 64.2–98.1 %. Chitosan hydrogel boosted the anti-inflammatory and antimicrobial properties of CHX.
Is part of
Hemmingsen, L.M. (2022). Advanced topical delivery systems for membrane-active antimicrobials. Exploring nature to improve antimicrobial wound therapy. (Doctoral thesis). https://hdl.handle.net/10037/27103.
Publisher
Elsevier
Citation
Hemmingsen LM, Giordani B, Pettersen AK, Vitali B, Basnet P, Skalko-Basnet N. Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro. Carbohydrate Polymers. 2021;262:117939
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