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dc.contributor.authorIakunchykova, Olena
dc.contributor.authorAverina, Maria
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorMalyutina, Sofia
dc.contributor.authorKudryavtsev, Alexander V
dc.contributor.authorCook, Sarah
dc.contributor.authorWild, Sarah
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorLeon, David A.
dc.date.accessioned2021-09-08T07:16:59Z
dc.date.available2021-09-08T07:16:59Z
dc.date.issued2021-03-04
dc.description.abstract<i>Introduction</i> - Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear.<br><br> <i>Research design and methods</i> - Prevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based studies: Know Your Heart (KYH) (Russia, 2015–2018, n=4121) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2016, n=17 649). Diabetes was defined by the level of glycated hemoglobin and/or self-reported diabetes and/or diabetes medication use. Marginal structural models were used to estimate the role of key risk factors for diabetes in differences between the studies.<br><br> <i>Results</i> - Age-standardized prevalence of diabetes was higher in KYH compared with Tromsø 7 in men (11.6% vs 6.2%) and in women (13.2% vs 4.3%). Age-adjusted ORs for diabetes in KYH compared with Tromsø 7 were 2.01 (95% CI 1.68 to 2.40) for men and 3.66 (95% CI 3.13 to 4.26) for women. Adiposity (body mass index and waist circumference) explained none of this effect for men but explained 46.0% (39.6, 53.8) for women. Addition of smoking and C reactive protein, as further mediators, slightly increased the percentage explained of the difference between studies to 55.5% (46.5, 66.0) for women but only to 9.9% (−0.6, 20.8) for men.<br><br> <i>Conclusions</i> - Adiposity is a key modifiable risk factor that appears to explain half of the almost threefold higher female prevalence of diabetes in Russia compared with Norway, but none of the twofold male difference.en_US
dc.identifier.citationIakunchykova, Averina, Wilsgaard, Malyutina, Kudryavtsev, Cook, Wild, Eggen, Hopstock, Leon. What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity. BMJ Open Diabetes Research & Care. 2021;9(1)en_US
dc.identifier.cristinIDFRIDAID 1918557
dc.identifier.doi10.1136/bmjdrc-2020-002021
dc.identifier.issn2052-4897
dc.identifier.urihttps://hdl.handle.net/10037/22443
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalBMJ Open Diabetes Research & Care
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleWhat factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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