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dc.contributor.authorPietropaolo, Valeria
dc.contributor.authorPrezioso, Carla
dc.contributor.authorMoens, Ugo
dc.date.accessioned2021-09-23T07:40:39Z
dc.date.available2021-09-23T07:40:39Z
dc.date.issued2021-08-03
dc.description.abstractThe tumor viruses human T-lymphotropic virus 1 (HTLV-1), hepatitis C virus (HCV), Merkel cell polyomavirus (MCPyV), high-risk human papillomaviruses (HR-HPVs), Epstein-Barr virus (EBV), Kaposi’s sarcoma-associated herpes virus (KSHV) and hepatitis B virus (HBV) account for approximately 15% of all human cancers. Although the oncoproteins of these tumor viruses display no sequence similarity to one another, they use the same mechanisms to convey cancer hallmarks on the infected cell. Perturbed gene expression is one of the underlying mechanisms to induce cancer hallmarks. Epigenetic processes, including DNA methylation, histone modification and chromatin remodeling, microRNA, long noncoding RNA, and circular RNA affect gene expression without introducing changes in the DNA sequence. Increasing evidence demonstrates that oncoviruses cause epigenetic modifications, which play a pivotal role in carcinogenesis. In this review, recent advances in the role of host cell epigenetic changes in virus-induced cancers are summarized.en_US
dc.identifier.citationPietropaolo V, Prezioso C, Moens u. Role of Virus-Induced Host Cell Epigenetic Changes in Cancer. International Journal of Molecular Sciences. 2021;22(8346)en_US
dc.identifier.cristinIDFRIDAID 1923743
dc.identifier.doi10.3390/ijms22158346
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/22621
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleRole of Virus-Induced Host Cell Epigenetic Changes in Canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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