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High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients

Permanent lenke
https://hdl.handle.net/10037/22626
DOI
https://doi.org/10.1038/s41598-021-93208-6
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article.pdf (2.348Mb)
Publisert versjon (PDF)
Dato
2021-07-05
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Støen, Maria Jenvin; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Ingebriktsen, Lise Martine; Bremnes, Roy M.; Dønnem, Tom; Lombardi, Ana Paola; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Richardsen, Elin
Sammendrag
MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulatory function of fundamental cellular processes. In many malignancies, up-regulation of miR-17-5p is associated with worse outcome. In PCa, miR-17-5p has been reported to increase cell proliferation and the risk of metastasis. In this study, prostatectomy specimens from 535 patients were collected. Tissue microarrays were constructed and in situ hybridization was performed, followed by scoring of miR-17-5p expression on different tumor compartments. High expression of miR-17-5p in tumor epithelium was associated with biochemical failure (BF, p < 0.001) and clinical failure (CF, p = 0.019). In multivariate analyses, high miR-17-5p expression in tumor epithelial cells was an independent negative prognostic factor for BF (HR 1.87, 95% CI 1.32–2.67, p < 0.001). In vitro analyses confirmed association between overexpression of miR-17-5p and proliferation, migration and invasion in prostate cancer cell lines (PC3 and DU145). In conclusion, our study suggests that a high cancer cell expression of miR-17-5p was an independent negative prognostic factor in PCa.
Forlag
Nature Research
Sitering
Støen, Andersen, Rakaee, Pedersen, Ingebriktsen, Bremnes, Dønnem, Lombardi, Kilvær, Rasmussen Busund, Richardsen. High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients. Scientific Reports. 2021;11
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  • Artikler, rapporter og annet (medisinsk biologi) [1103]
Copyright 2021 The Author(s)

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