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dc.contributor.authorHolte, Kari
dc.contributor.authorErsdal, Hege Langli
dc.contributor.authorKlingenberg, Claus
dc.contributor.authorEilevstjønn, Joar
dc.contributor.authorStigum, Hein
dc.contributor.authorJatosh, Samwel
dc.contributor.authorKidanto, Hussein
dc.contributor.authorStørdal, Ketil
dc.date.accessioned2021-10-14T09:21:09Z
dc.date.available2021-10-14T09:21:09Z
dc.date.issued2021-06-03
dc.description.abstract<i>Aim</i> - To explore and compare expired CO<sub>2</sub> (ECO<sub>2</sub>) and heart rate (HR), during newborn resuscitation with bag-mask ventilation, as predictors of 24-h outcome.<br><br> <i>Methods</i> - Observational study from March 2013 to June 2017 in a rural Tanzanian hospital. Side-stream measures of ECO<sub>2</sub>, ventilation parameters, HR, clinical information, and 24-h outcome were recorded in live born bag-mask ventilated newborns with initial HR < 120 bpm. We analysed the data using logistic regression models and compared areas under the receiver operating curves (AUC) for ECO<sub>2</sub> and HR within three selected time intervals after onset of ventilation (0–30 s, 30.1–60 s and 60.1–300 s).<br><br> <i>Results</i> - Among 434 included newborns (median birth weight 3100 g), 378 were alive at 24 h, 56 had died. Both ECO<sub>2</sub> and HR were independently significant predictors of 24-h outcome, with no differences in AUCs. In the first 60 s of ventilation, ECO<sub>2</sub> added extra predictive information compared to HR alone. After 60 s, ECO<sub>2</sub> lost significance when adjusted for HR. In 70% of newborns with initial ECO<sub>2</sub> <2% and HR < 100 bpm, ECO<sub>2</sub> reached ≥2% before HR ≥ 100 bpm. Survival at 24 h was reduced by 17% per minute before ECO<sub>2</sub> reached ≥2% and 44% per minute before HR reached ≥100 bpm.<br><br> <i>Conclusions</i> - Higher levels and a faster rise in ECO<sub>2</sub> and HR during newborn resuscitation were independently associated with improved survival compared to persisting low values. ECO<sub>2</sub> increased before HR and may serve as an earlier predictor of survival.en_US
dc.identifier.citationHolte, Ersdal, Klingenberg, Eilevstjønn, Stigum, Jatosh, Kidanto, Størdal. Expired carbon dioxide during newborn resuscitation as predictor of outcome. Resuscitation. 2021:1-8en_US
dc.identifier.cristinIDFRIDAID 1920322
dc.identifier.doi10.1016/j.resuscitation.2021.05.018
dc.identifier.issn0300-9572
dc.identifier.issn1873-1570
dc.identifier.urihttps://hdl.handle.net/10037/22765
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalResuscitation
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/GLOBVAC/228203/Norway/Safer Births- new knowledge and innovations to decrease perinatal mortality and morbidity worldwide/GLOBVAC/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleExpired carbon dioxide during newborn resuscitation as predictor of outcomeen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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