Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
Permanent lenke
https://hdl.handle.net/10037/23605Dato
2021-09-21Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Schulte Werning, Laura; Murugaiah, Anjanah; Singh, Bhupender; Johannessen, Mona; Engstad, Rolf Einar; Skalko-Basnet, Natasa; Holsæter, Ann MariSammendrag
An active wound dressing should address the main goals in wound treatment, which
are improved wound healing and reduced infection rates. We developed novel multifunctional
nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan
(βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated
from the cell walls of Saccharomyces cerevisiae and from shrimp shells, respectively. To evaluate the
effect of each active ingredient on the nanofibers’ morphological features and bioactivity, nanofibers
with both βG and CHI, only βG, only CHI and only copolymers, polyethylene oxide (PEO) and
hydroxypropylmethylcellulose (HPMC) were fabricated. All four nanofiber formulations were
also prepared with 1% CAM. The needle-free NanospiderTM technique allowed for the successful
production of defect-free nanofibers containing all three active ingredients. The CAM-containing
nanofibers had a burst CAM-release and a high absorption capacity. Nanofibers with all active
ingredients (βG, CHI and CAM) showed a concentration-dependent anti-inflammatory activity,
while maintaining the antimicrobial activity of CAM. The promising anti-inflammatory properties,
together with the high absorption capacity and antimicrobial effect, make these multifunctional
nanofibers promising as dressings in local treatment of infected and exuding wounds, such as
burn wounds
Forlag
MDPISitering
Schulte Werning, Murugaiah, Singh, Johannessen, Engstad, Skalko-Basnet, Holsæter. Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning. Pharmaceutics. 2021;13(9)Metadata
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Copyright 2021 The Author(s)