Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer
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https://hdl.handle.net/10037/23904Date
2021-12-10Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Mao, Ziling; Aglago, Elom K.; Zhao, Zhiwei; Schalkwijk, Casper C; Jiao, Li; Freisling, Heinz; Weiderpass, Elisabete; Hughes, David J.; Eriksen, Anne Kirstine; Tjønneland, Anne; Gianluca, Severi; Rothwell, Joseph A; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kaaks, Rudolf; Birukov, Anna; Schulze, Matthias B; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-Mesquita, Bas; Vermeulen, Roel C.H.; Gram, Inger Torhild; Skeie, Guri; Sandanger, Torkjel M; Quiros, J Ramon; Crous-Bou, Marta; Sanchez, Maria-Jose; Amiano, Pilar; Chirlaque, Maria-Dolores; Barricarte Gurrea, Aurelio; Manjer, Jonas; Johansson, Ingegerd; Perez-Cornago, Aurora; Jenab, MazdaAbstract
Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation
and have been linked to multiple chronic diseases, including cancer. However, the association of
AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated.
Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and
all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective
Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs
were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases
died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with
all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive
association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II
diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment
and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause
mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by
sex, diabetes status, and timing of exposure to AGEs are warranted.
Publisher
MDPICitation
Mao, Aglago EK, Zhao Z, Schalkwijk CC, Jiao L, Freisling H, Weiderpass E, Hughes DJ, Eriksen AK, Tjønneland A, Gianluca, Rothwell JA, Boutron-Ruault M, Katzke V, Kaaks R, Birukov, Schulze MB, Krogh V, Panico S, Tumino R, Ricceri F, Bueno-De-Mesquita B, Vermeulen RC, Gram IT, Skeie G, Sandanger TM, Quiros JR, Crous-Bou M, Sanchez M, Amiano P, Chirlaque M, Barricarte Gurrea A, Manjer J, Johansson I, Perez-Cornago A, Jenab M, Fedirko V. Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer. Nutrients. 2021;13(12):443Metadata
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