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Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics

Permanent link
https://hdl.handle.net/10037/24081
DOI
https://doi.org/10.1016/j.csbj.2021.12.012
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Date
2021-12-20
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Pettersen, Veronika K.; Antunes, Luis Caetano Martha; Dufour, A; Arrieta, Marie-Claire
Abstract
Humans have a long-standing coexistence with microorganisms. In particular, the microbial community that populates the human gastrointestinal tract has emerged as a critical player in governing human health and disease. DNA and RNA sequencing techniques that map taxonomical composition and genomic potential of the gut community have become invaluable for microbiome research. However, deriving a biochemical understanding of how activities of the gut microbiome shape host development and physiology requires an expanded experimental design that goes beyond these approaches. In this review, we explore advances in high-throughput techniques based on liquid chromatography– mass spectrometry. These omics methods for the identification of proteins and metabolites have enabled direct characterisation of gut microbiome functions and the crosstalk with the host. We discuss current metaproteomics and metabolomics workflows for producing functional profiles, the existing methodological challenges and limitations, and recent studies utilising these techniques with a special focus on early life gut microbiome.
Publisher
Elsevier
Citation
Pettersen V, Antunes, Dufour A, Arrieta M. Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics. Computational and Structural Biotechnology Journal. 2021
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  • Artikler, rapporter og annet (medisinsk biologi) [1103]
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