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dc.contributor.authorItaguchi, Yoshihiro
dc.contributor.authorCastro Chavira, Susana Angelica
dc.contributor.authorWaterloo, Knut
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorRodríguez-Aranda, Claudia
dc.date.accessioned2022-02-17T13:19:13Z
dc.date.available2022-02-17T13:19:13Z
dc.date.issued2022-01-12
dc.description.abstractSemantic verbal fluency (VF), assessed by animal category, is a task widely used for early detection of dementia. A feature not regularly assessed is the occurrence of errors such as perseverations and intrusions. So far, no investigation has analyzed the how and when of error occurrence during semantic VF in aging populations, together with their possible neural correlates. The present study aims to address the issue using a combined methodology based on latent Dirichlet allocation (LDA) analysis for word classification together with a time-course analysis identifying exact time of errors’ occurrence. LDA is a modeling technique that discloses hidden semantic structures based on a given corpus of documents. We evaluated a sample of 66 participants divided into a healthy young group (n = 24), healthy older adult group (n = 23), and group of patients with mild Alzheimer’s disease (AD) (n = 19). We performed DTI analyses to evaluate the white matter integrity of three frontal tracts purportedly underlying error commission: anterior thalamic radiation, frontal aslant tract, and uncinate fasciculus. Contrasts of DTI metrics were performed on the older groups who were further classified into high-error rate and low-error rate subgroups. Results demonstrated a unique deployment of error commission in the patient group characterized by high incidence of intrusions in the first 15 s and higher rate of perseverations toward the end of the trial. Healthy groups predominantly showed very low incidence of perseverations. The DTI analyses revealed that the patients with AD committing high-error rate presented significantly more degenerated frontal tracts in the left hemisphere. Thus, our findings demonstrated that the appearance of intrusions, together with left hemisphere degeneration of frontal tracts, is a pathognomic trait of mild AD. Furthermore, our data suggest that the error commission of patients with AD arises from executive and working memory impairments related partly to deteriorated left frontal tracts.en_US
dc.identifier.citationItaguchi, Castro Chavira, Waterloo, Johnsen, Rodríguez-Aranda. Evaluation of error production in animal fluency and its relationship to frontal tracts in normal aging and mild Alzheimer's disease: A combined LDA and time-course analysis investigation. Frontiers in Aging Neuroscience. 2021;13:1-18en_US
dc.identifier.cristinIDFRIDAID 1988396
dc.identifier.doi10.3389/fnagi.2021.710938
dc.identifier.issn1663-4365
dc.identifier.urihttps://hdl.handle.net/10037/24083
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Aging Neuroscience
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleEvaluation of error production in animal fluency and its relationship to frontal tracts in normal aging and mild Alzheimer's disease: A combined LDA and time-course analysis investigationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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