Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
Permanent lenke
https://hdl.handle.net/10037/24085Dato
2021-08-04Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Londono, Catalina; Cayssials, Valerie; de Villasante, Izar; Crous-Bou, Marta; Scalbert, Augustin; Weiderpass, Elisabete; Agudo, Antonio; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Katzke, Verena; Schulze, Matthias; Palli, Domenico; Krogh, Vittorio; De Magistris, Maria Santucci; Tumino, Rosario; Ricceri, Fulvio; Gram, Inger Torhild; Rylander, Charlotta; Skeie, Guri; Sanchez, Maria-Jose; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Sartor, Hanna; Sonestedt, Emily; Esberg, Anders; Idahl, Annika; Mahamat-Saleh, Yahya; Laouali, Nasser; Kvaskoff, Marina; Turzanski-Fortner, Renée; Zamora-Ros, RaulSammendrag
Despite some epidemiological evidence on the protective effects of polyphenol intake on
epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective
studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the
associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a
large prospective study. The study was conducted in the European Prospective Investigation into
Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from
the general population. Polyphenol intake was assessed through validated country-specific dietary
questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first
incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours)
were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest
quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI
0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were
not related to either overall EOC risk or any EOC subtype. A borderline statistically significant
positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43;
p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although
these associations did not exceed the Bonferroni correction threshold. The current results do not
support any association between polyphenol intake and EOC in our large European prospective
study. Results regarding phenolic acid intake need further investigation
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MDPISitering
Londono, Cayssials V, de Villasante, Crous-Bou M, Scalbert A, Weiderpass E, Agudo A, Tjønneland A, Olsen A, Overvad K, Katzke V, Schulze M, Palli D, Krogh V, De Magistris MS, Tumino R, Ricceri F, Gram IT, Rylander C, Skeie G, Sanchez M, Amiano P, Huerta JM, Barricarte A, Sartor H, Sonestedt E, Esberg A, Idahl A, Mahamat-Saleh Y, Laouali N, Kvaskoff M, Turzanski-Fortner R, Zamora-Ros R. Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study . Antioxidants. 2021;10(8)Metadata
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