Sperm mitochondrial DNA copy numbers in normal and abnormal semen analysis: A systematic review and meta-analysis
Permanent lenke
https://hdl.handle.net/10037/24111Dato
2021-12-25Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
Objectives: To summarise the evidence from literature regarding the association of mitochondrial DNA copy numbers and semen quality with a particular emphasis on the sperm motility.
Search strategy: Standard methodology recommended by Cochrane.
Selection criteria: All published primary research reporting on the association between mitochondrial DNA copy numbers and semen quality.
Data collection and analysis: Using standard methodology recommended by Cochrane we pooled results using a random effects model and the findings were reported as a standardised mean difference.
Main results: We included ten studies. The primary outcome was sperm mitochondrial DNA copy numbers. A meta-analysis including five studies showed significantly higher mitochondrial DNA copy numbers in abnormal semen analysis compared with normal semen analysis (standardised mean difference 1.08, 95% CI 0.74–1.43). Seven studies included in the meta-analysis showed a significant negative correlation between mitochondrial DNA copy numbers and semen parameters. The quality of evidence was assessed as good to very good in 60% of studies.
Conclusions: Our review demonstrates significantly higher mitochondrial DNA in human sperm cells of men with abnormal semen analysis in comparison to men with normal semen analysis.